A Hormone's hidden power: could progesterone be the key to unexplained infertility?

NCT ID NCT07738068

Not yet recruiting Disease control Sponsor: Simone Broer Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This phase 3 trial investigates whether taking progesterone during the luteal phase of the menstrual cycle can increase the chance of a live birth for couples with unexplained infertility. Participants take either progesterone or a placebo twice daily for up to six months while tracking their cycles at home. The study aims to answer whether this simple hormone support can make a difference when no other cause for infertility is found.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: progesterone (Utrogestan 200 mg soft capsules)
What this could lead to: If effective, progesterone could offer a simple, low-cost treatment to improve pregnancy chances for couples with unexplained infertility.
What could go wrong: This is a phase 3 trial, but previous smaller studies have shown mixed results. Progesterone may not increase live birth rates and could cause side effects like drowsiness or bloating.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

female infertility infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FEMALE INFERTILITY INFERTILITY INFERTILITY PRIMARY INFERTILITY SECONDARY SUBFERTILITY SUBFERTILITY, FEMALE

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