INFERTILITY

This study tests whether adding a substance called hyaluronan to the liquid used during embryo transfer can improve pregnancy rates in IVF. Researchers will compare live birth rates between women whose embryos are placed in a hyaluronan-rich medium versus a standard one. The tria…

This Phase 3 trial tests a new combination of two hormones (follitropin alfa and lutropin alfa) against a standard treatment (hMG) for Japanese women with LH and FSH deficiency who are undergoing IVF. The goal is to see which treatment helps produce more eggs for retrieval. About…

This phase 3 trial tests whether tamoxifen or letrozole works better for preserving fertility in women with estrogen-sensitive breast cancer before starting chemotherapy. About 309 participants will take one of the two drugs during ovarian stimulation to freeze their eggs. The ma…

This study tests a method to sort sperm by gender (X or Y chromosome) using a density gradient. The goal is to help couples undergoing IVF or insemination have a baby of a desired sex, for medical or personal reasons. About 2000 couples will take part, and researchers will check …

This study looks at 100 women with infertility to see how common chronic endometritis (a long-term inflammation of the womb lining) is and whether antibiotic treatment can improve their chances of getting pregnant and having a healthy baby. Participants will have a camera test an…

This study tests whether a cheaper hormone (dydrogesterone) works as well as a standard drug (GnRH antagonist) to prevent early ovulation in women with low ovarian response undergoing double ovarian stimulation. About 120 women will be randomly assigned to one of the two treatmen…

This study tests whether performing intrauterine insemination (IUI) at 42 hours after a hormone trigger shot leads to more live births than the standard 36-hour timing. About 692 women with infertility will be randomly assigned to one of the two timing groups. The goal is to see …

This phase 3 trial compares two ways to prepare the womb lining for a frozen embryo transfer: a modified natural cycle using progesterone only, versus standard hormone replacement therapy. The study will enroll 336 women aged 21-44 with regular cycles to see which method leads to…

This study looks at whether surgically removing deep endometriosis from the bowel before IVF improves pregnancy rates compared to IVF alone. It includes 120 women with infertility and pain from deep endometriosis. Participants are randomly assigned to either have surgery then IVF…

This pilot study tests whether transplanting a man's own frozen testicular tissue, stored before childhood cancer treatment, can restore fertility. Twenty men with azoospermia (no sperm) who want children will undergo the procedure. Doctors will check if the graft produces sperm …

This study tests whether using special devices during embryo transfer can help more IVF patients get pregnant. The devices keep the embryo at the right temperature and control the transfer process to reduce human error. About 160 women having frozen embryo transfers will be rando…

This Phase 2 trial is testing whether a fixed dose of the hormone follitropin delta (Rekovelle) can improve ovarian stimulation for intrauterine insemination (IUI) in women with regular cycles. The goal is to promote the growth of two mature eggs per cycle to increase pregnancy c…

This study tests whether adding a hormone called LH to standard IVF treatment helps women over 35 who had a low number of eggs in previous cycles. Participants will receive either the usual FSH hormone alone or FSH plus LH, and researchers will measure hormone levels on the day o…

This phase 3 trial tests whether a lower daily dose (600 mg) of vaginal progesterone works as well as the standard dose (800 mg) for supporting pregnancy after a frozen embryo transfer. About 1,020 women undergoing IVF will be randomly assigned to one of the two doses. The main g…

This study tests a new automated system called AURA that handles sperm, eggs, and embryos during IVF. About 150 patients will have their samples processed by the machine, while some eggs are handled the usual way for comparison. The goal is to see if the robot can perform lab tas…

This study looks at whether giving levothyroxine (a thyroid hormone medication) to women with subclinical hypothyroidism (a mild underactive thyroid) can improve their chances of having a baby through IVF. About 900 women aged 18-45 will be included, and researchers will compare …

This study tests whether giving growth hormone or DHEA (a natural hormone) can improve egg production and pregnancy rates in women with poor ovarian reserve who are undergoing IVF. 165 women will receive one of these treatments or a placebo (folic acid only) for 1-3 months before…

This study tests whether treating eggs and sperm before fertilization can help people who have had complete failure with standard IVF or one prior ICSI cycle. Researchers will measure fertilization rates and embryo development. The goal is to improve chances of pregnancy for thos…

This study offers boys aged 0-17 the chance to freeze testicular tissue before undergoing treatments like chemotherapy or radiation that could cause permanent infertility. The tissue is stored for potential future use to achieve pregnancy. Researchers will track whether transplan…

This study compares taking the fertility drug letrozole for 10 days versus the usual 5 days in women with PCOS who want to get pregnant. About 20 women aged 18-40 will be randomly assigned to one of the two groups. The goal is to see if the longer treatment leads to more ovulatio…

This study compares a generic version of the drug cetrorelix acetate to the original brand in women undergoing IVF. The goal is to see if the generic works just as well at preventing early ovulation and improving live birth rates. Over 1,300 women will participate, and the result…

This study tests whether transplanting a woman's own frozen ovarian tissue can restore fertility after cancer treatment. Ten women who became infertile due to chemotherapy or radiation will receive the transplant. The goal is to see if they can get pregnant and have normal menstr…

This study is testing whether a simple ultrasound procedure, called saline infusion sonohysterography (SIS), can accurately detect pelvic adhesions (scar tissue) in infertile women. Researchers will compare SIS results to those from laparoscopy, the current standard. If SIS prove…

This study tests whether warming the contrast dye used in a hysterosalpingogram (HSG) — a standard X-ray test for blocked fallopian tubes — can reduce pain and cramping during the procedure. About 240 women aged 18–45 will be randomly assigned to receive either warm or room-tempe…

This study tests whether inhaling lavender essential oil for four weeks can reduce anxiety, stress, and depression in women waiting for IVF treatment. 120 women will be split into three groups: one using real lavender oil, one using a placebo scent, and one receiving no scent. Th…

This study tests whether pentoxyfilline, a drug that improves blood flow, can thicken the uterine lining and increase pregnancy rates in women with unexplained infertility undergoing frozen embryo transfer. About 100 women with good-quality embryos will receive the drug or a plac…

This study tests whether taking semaglutide (a weight-loss medication) for 12 weeks before starting IVF can lead to better-quality embryos in overweight or obese women. About 62 women aged 38 or younger with a BMI between 27 and 40 will be randomly assigned to receive semaglutide…

This study tests whether a sedative called remimazolam, combined with alfentanil, can lower the chance of low oxygen levels (hypoxia) during egg retrieval for IVF. About 400 women aged 18-50 will be randomly assigned to receive either remimazolam or the standard drug propofol. Th…

This study tests whether atosiban, a drug that relaxes the womb, can improve live birth rates in women who have had previous IVF failures and have abnormal womb contractions. About 792 women aged 20-40 will receive either atosiban or a placebo before a single embryo transfer. The…

This study compares two embryo transfer liquids—one with a high amount of hyaluronic acid (a natural 'sticky' substance) and one with a low amount—to see which leads to more live births. About 858 women having a single embryo transfer will take part. The goal is to find out if th…

This study tests a new ultra-rapid freezing method for embryos (blastocysts) in women receiving donor eggs. The goal is to see if this faster approach is as safe and effective as the standard freezing method. Researchers will compare how many embryos survive thawing and how many …

This study aims to understand how reproductive disorders, such as delayed or early puberty, are inherited. Researchers will collect blood samples and medical histories from 850 people with these conditions and their family members. No treatment is provided; the goal is to identif…

This study collects and stores ovarian tissue from females aged 4 to 35 who choose to freeze a sample before cancer treatment that could harm their fertility. Researchers will also gather medical data and annual surveys for up to 30 years. The goal is to build a national database…

This study tracks immune-related substances in the blood of 40 women undergoing a frozen embryo transfer. Researchers want to see how these markers change before and after the transfer, and whether they relate to pregnancy success. The goal is to better understand the role of the…

This study tests a new AI-assisted platform called IntelliWell to find rare sperm cells in testicular tissue from men with non-obstructive azoospermia, a condition where standard analysis finds no sperm. The platform processes tissue that would otherwise be discarded, and if sper…

This study looks at why some people's fertility treatments don't work. Researchers will follow 5,000 infertile patients (half men, half women) to see how things like pollution from plastics, daily habits, and social factors affect the chance of having a baby through treatments li…

This study looks at how the age of the male partner and the way sperm is chosen might affect embryo growth in IVF. About 100 couples having their first IVF cycle will take part. Researchers will compare a special sperm selection device (Zymot) with the usual method to see which l…

This study uses embryos that were not used in fertility treatments to help researchers learn how to improve freezing methods and develop tests that predict which embryos are most likely to lead to a successful pregnancy. The goal is to make in vitro fertilization (IVF) more effec…

This study looks at whether performing assisted hatching on day 3 or day 5-7 of embryo development leads to better outcomes in IVF. Researchers will compare blastulation rates and embryo quality in 75 participants. The goal is to find the optimal timing for this common lab proced…

This study looks at 300 women who had a C-section and are now having trouble getting pregnant or have other symptoms. Researchers use a special ultrasound called saline infusion sonohysterography (SIS) to check the scar on the uterus. The goal is to see how well SIS finds scar de…

This study gathers information from female Canadian Armed Forces members and Veterans about their reproductive health, including contraception, pregnancy, infertility, and pelvic floor issues. Researchers will use surveys and interviews to learn about their experiences, access to…

This study looks at how pesticides and the bacteria in your gut and genital tract might be linked to endometriosis and infertility. Researchers will compare 160 women with and without endometriosis to find patterns in their DNA and bacteria. The goal is to better understand the d…

This study is for women undergoing frozen embryo transfer with hormone replacement therapy. It aims to see if higher progesterone levels on the day of transfer lead to higher pregnancy rates. Researchers will track 370 participants to better understand this link and improve ferti…

This study is testing a new technique called diamond magnetometry to measure free radicals in individual sperm cells and blood. Free radicals are natural but can damage sperm if out of balance. Researchers will also look at the bacteria in semen and how lifestyle and diet affect …

This study follows 900 couples in Paris who tried preimplantation genetic diagnosis (PGD) to avoid passing on a severe genetic disease but did not have a baby from it. Researchers want to know how many later have a healthy child naturally, through other treatments, or decide to s…

This study tests whether an artificial intelligence program called STIMAI® can help choose the best day to give the final 'trigger' shot in IVF, compared to doctors making the decision alone. About 644 women undergoing ovarian stimulation for IVF will be randomly assigned to eith…

This study compares two sperm collection timings—1 hour versus the usual 2-5 days of abstinence—to see which leads to more embryos with normal chromosomes during IVF. Researchers will track embryo health and pregnancy rates in 187 women. The goal is to find a simple way to improv…

This study looks at how the natural microbes and chemical profiles in couples' bodies relate to IVF outcomes. Researchers will collect samples from 1000 couples and track whether they have a baby, miscarriage, or other pregnancy results. The goal is to find patterns that might he…

This study compares two ways to screen embryos in women with polycystic ovary syndrome (PCOS) undergoing IVF. One method looks at DNA methylation patterns (PIMS), while the other checks for chromosome issues (PGT-A). The goal is to see if PIMS can lower the rate of early pregnanc…

This study looks at whether blood-thinning medications (like aspirin or heparin) can improve the uterine lining and pregnancy rates in women struggling with infertility. Researchers will use special ultrasound scans to measure the womb's thickness, blood flow, and movement in abo…

This study tracks 356 women undergoing frozen embryo transfer to see how different hormone preparations affect uterine contractions (called endometrial peristalsis) and pregnancy rates. Researchers will measure contractions at three key times and link them to pregnancy outcomes. …

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis or infertility. The goal is to understand the role of certain proteins in this process. No treatm…

This study compares two common forms of vaginal progesterone—soft capsules and pessaries—used during frozen embryo transfer. Researchers want to see which one women find more satisfying, convenient, and tolerable. About 400 women will use one of the two forms and report their exp…

This study looks at how infertility and fertility treatments like IVF affect women's sexual function and behavior. About 500 women under 45 with infertility will fill out an anonymous questionnaire about their sexual desire, satisfaction, and activities. The goal is to help docto…

This study is looking at how things in your everyday environment, like chemicals from plastics or air pollution, and personal habits, such as diet and stress, might affect the success of fertility treatments like IVF. Researchers will follow about 5,000 couples in China who are a…

This study will follow 2,500 Chinese women who are prescribed REKOVELLE for the first time during IVF or ICSI treatments. Researchers will track how the drug is used in routine practice, its effectiveness (including live birth rates), and any side effects. The goal is to understa…

This study looks at how physical activity, fitness, stress, and sleep affect pregnancy rates in women receiving fertility treatments like IVF or IUI. Researchers will track 115 women aged 18-43 to see if being more active improves their chances of getting pregnant. The goal is to…

This study compares the usual timing of the 'trigger' shot in IVF with a 1-2 day delay. Researchers want to see if waiting longer leads to more high-quality embryos and higher live birth rates. About 834 women undergoing their first or second IVF cycle will take part.

This study is testing whether an artificial intelligence tool can analyze 3D ultrasound images of the ovaries to better predict how well a woman will respond to fertility treatments like IVF. Researchers will enroll about 4,000 patients undergoing ovarian stimulation. The goal is…

This study watches blood sugar levels in 100 women getting fertility treatments like IVF. Participants wear a continuous glucose monitor to track sugar changes. The goal is to see if these changes affect pregnancy results. This is an observation-only study, not a treatment.

This study looks at how things in your environment—like pollution, chemicals, diet, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like low or high hormone levels, early or late puberty, or inf…

This study looks at whether low levels of a protein called mannose-binding lectin (MBL) in the blood are linked to repeated pregnancy loss or failed IVF attempts. Researchers will measure MBL levels in 500 women with these conditions and compare them to the general population. Th…

This study tests whether a new automated system can freeze human eggs and embryos as effectively as the current manual method. Researchers will compare survival rates after thawing between the two methods using surplus eggs and embryos from 125 IVF patients. If successful, automa…

This study looks at whether chlordecone, a pesticide still present in the environment in Guadeloupe, is linked to fertility problems in women. Researchers will measure a key fertility hormone (AMH) and count egg follicles in 634 women seeking fertility treatment. The goal is to u…

This study looks at whether levels of Anti-Müllerian hormone (AMH) in the fluid around a woman's eggs can predict if an embryo has the right number of chromosomes. Researchers will collect fluid from one follicle in each ovary during egg retrieval in 300 women undergoing IVF. The…

This study looks at how searching for health information online affects stress and emotional well-being in women going through infertility treatment. Researchers will survey about 200 women to understand their online search habits, stress levels, and overall mental health. The go…

This study uses artificial intelligence to analyze vaginal ultrasound images of the uterine lining taken during routine IVF treatment. The goal is to see if the AI can predict whether an embryo will successfully implant. Researchers will enroll 1,500 women aged 18-40 undergoing I…

This study is looking at how the uterus expands (distension) during a special ultrasound procedure in women who are having trouble getting pregnant and are undergoing IVF or ICSI. Researchers will compare these women to fertile women to see if there are differences. The goal is t…