INFERTILITY

This study tests a new way to prepare sperm for in vitro fertilization (IVF) called HyperSperm. It compares the safety and effectiveness of this method to standard sperm preparation. The trial will involve 202 couples undergoing IVF and will measure how many embryos are healthy (…

This study tests whether a type of abdominal massage called visceral osteopathic manual therapy can improve sperm quality and blood flow in men with varicocele, a condition where veins in the scrotum become enlarged and can cause infertility. Thirty-two men aged 18-45 will either…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase pregnancy rates. About 288 women with infertility will be randomly assigned to receive either standard IUI or IUI with PRP-treated…

This study looks at whether surgically removing uterine fibroids (myomectomy) before in vitro fertilization (IVF) helps women with infertility have a baby. About 792 women aged 20-39 with fibroids 4-6 cm that do not distort the uterine cavity will be randomly assigned to either h…

This study compares giving three doses of a GnRH agonist (triptorelin) versus the usual single dose to trigger ovulation in women who produce many eggs during IVF. The goal is to see if multiple doses lead to more mature eggs and higher pregnancy rates. The trial plans to enroll …

This study tests whether giving two medications (a GnRH agonist and HCG) instead of just HCG can help women with low ovarian response produce more mature eggs for IVF. About 164 women will be randomly assigned to receive either the double trigger or the standard HCG trigger. The …

This Phase 3 trial will test whether adding a traditional Chinese herbal formula to the standard fertility drug letrozole can improve natural pregnancy rates in women aged 22–39 with diminished ovarian reserve (low egg supply). The study plans to enroll 320 women who will receive…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase the chance of pregnancy. About 288 women with infertility will be randomly assigned to receive either PRP-treated sperm or standar…

This study will compare two advanced sperm selection techniques—PICSI and the ZyMot device—used during ICSI (a type of IVF). The goal is to see which method leads to more pregnancies. 300 couples will take part, with women aged 20-39. The results could help fertility clinics choo…

This study tests whether a 12-week program of diet changes, supplements, exercise, and better sleep can improve fertility scores in women aged 20-40 who show early signs of fertility decline. Researchers will enroll 384 women across six medical centers in China, using the OvaRePr…

This study tests a 5-day online Theta Healing program—including meditation, visualization, and self-compassion exercises—in 142 women with PCOS. The goal is to see if it reduces fertility anxiety and improves body image compared to usual care alone. Results will be measured 6 wee…

This study looks at a fertility drug called corifollitropin alfa in women aged 36 to 40 who are doing IVF. The goal is to see if the drug is safe and helps produce eggs. Researchers will track side effects and pregnancy rates over one year.

This study tests whether taking progesterone (a hormone) after intrauterine insemination (IUI) increases the chance of pregnancy in women who also took letrozole to stimulate their ovaries. About 690 women in Denmark will be randomly assigned to receive either progesterone vagina…

This study looks at whether a gamified healthy lifestyle training program can help women going through fertility treatments (like IVF) adopt healthier habits and feel more in control. About 105 women will be split into three groups: one gets the game-like program plus a booklet, …

This study tests whether intravenous lidocaine or magnesium sulfate can better stabilize blood pressure and heart rate as women wake up from general anesthesia during infertility-related laparoscopic surgery. Sixty-nine women will be randomly assigned to receive one of the two dr…

This study tests whether adding pure platelet-rich plasma (P-PRP) to sperm samples can improve sperm movement (motility) in a lab. Researchers will first standardize how to make P-PRP, then compare sperm quality after 24 hours with and without P-PRP. The trial involves 248 partic…

This study looks at whether the natural contractions of the uterus (called endometrial peristalsis) influence the chance of pregnancy in women undergoing frozen embryo transfer with hormone replacement therapy. Researchers will measure these contractions using ultrasound at three…

This study will look back at records from 92 IVF patients whose embryos came from abnormally fertilized eggs. Researchers want to see how often these embryos lead to pregnancy and live birth. The goal is to help fertility doctors make better decisions about whether to use such em…

This large observational study will follow 4,000 young cancer survivors (ages 15-39) across Europe to understand how different cancer treatments impact fertility, hormone function, and pregnancy outcomes. Researchers will also evaluate the safety and success of fertility preserva…

This study will follow 3,000 young women (ages 15-39) with cancer to understand how treatments like chemotherapy and immunotherapy impact their fertility, pregnancy outcomes, and quality of life. Researchers will also look at the safety and success of fertility preservation metho…

This study follows 1,000 young men (ages 15-39) diagnosed with cancer to understand how treatments affect their fertility and hormone levels over time. Researchers will collect medical history, semen samples, and blood tests before and after therapy to identify who is at risk for…

This study will measure microplastics in semen, follicular fluid, and other samples from 1000 men and women seeking fertility treatment. Researchers will check if higher microplastic levels are linked to lower pregnancy rates and poorer egg or sperm quality. The goal is to better…

This study tests whether co-culturing immature human eggs with lab-grown ovarian support cells (made from stem cells) helps them mature in the lab. About 100 women undergoing IVF will donate leftover immature eggs, which will be split into two groups: one with standard lab matura…

This study will check the heart and blood vessel health of 120 women, some planning pregnancy naturally and some after IVF for infertility. Researchers want to see if infertility or IVF treatments are linked to higher heart disease risk. The goal is to learn how to run a larger s…

This study looks at a hormone called relaxin in women who get pregnant through IVF. Researchers want to see if relaxin levels differ between fresh and frozen embryo transfers, and if low levels are linked to pregnancy complications. 60 first-time mothers will give an extra blood …

This study looks at whether having a tattoo affects the chances of getting pregnant through IVF. Researchers will compare pregnancy rates in women with and without tattoos who are undergoing embryo transfer. The goal is to see if tattoo size, duration, or ink color play a role in…

This study will examine tissue samples from 30 women having surgery for bowel endometriosis to see if genetic changes in the affected bowel might increase the risk of colorectal cancer. The goal is to better understand any hidden connection and improve how doctors assess cancer r…

This study looks at how different microbes (like bacteria and viruses) spread between couples who are having trouble getting pregnant. Researchers will collect samples from the mouth and genitals of 200 couples over two years. The goal is to understand infection risks and improve…

This study will survey 233 married women aged 18-45 who are seeking infertility treatment in Egypt to find out how common violence is against them. Researchers want to understand if infertility makes women more likely to experience abuse. The goal is to use this information to be…

This pilot study will test whether it is safe and effective to remove uterine fibroids and retrieve eggs in a single surgical step for infertile women aged 18–45. The researchers will track pregnancy, miscarriage, and live birth rates after frozen embryo transfer. Only 20 women w…

This study will analyze videos of developing embryos from 1,500 IVF cycles to see if a computer algorithm can predict which ones will successfully implant in the womb. Researchers will combine embryo growth patterns with patient health data to train the algorithm. The goal is to …