INFERTILITY

This study tests whether taking semaglutide (a weight-loss medication) for 12 weeks before starting IVF can improve the quality of embryos in women who are overweight or obese. About 62 women aged 38 or younger with a BMI between 27 and 40 will be randomly assigned to receive sem…

This study tests whether using special devices during embryo transfer can help more IVF patients get pregnant. The devices keep the embryo at the right temperature and control the transfer process to reduce human error. About 160 women having frozen embryo transfers will be rando…

This study tests whether taking letrozole for 10 days instead of the usual 5 days helps more women with PCOS ovulate and get pregnant. About 84 women aged 18-40 will be randomly assigned to one of the two treatment schedules. The main goal is to see if the longer course leads to …

This study tests a new combination of fertility drugs (follitropin alfa and lutropin alfa) against a standard treatment (hMG) for Japanese women with low levels of two key hormones (LH and FSH) who are undergoing in vitro fertilization (IVF). The goal is to see if the new drug he…

This study offers boys aged 0-17 the chance to freeze testicular tissue before starting treatments like chemotherapy or radiation that could cause infertility. The goal is to use this tissue later to help them have biological children. Researchers will track how many pregnancies …

This study looks at whether levothyroxine, a common thyroid medication, can improve pregnancy rates in women with subclinical hypothyroidism (a mild underactive thyroid) who are undergoing IVF. About 900 women aged 18-45 will be included. Researchers will compare those who receiv…

This study compares a generic version of cetrorelix acetate to the original drug for women undergoing IVF. About 1,338 women will receive either the generic or original drug during ovarian stimulation. The goal is to see if the generic works just as well in helping achieve a live…

This study is for women with regular cycles who are trying to get pregnant through intrauterine insemination (IUI). Researchers want to see if a fixed, low dose of the hormone follitropin delta can stimulate the ovaries to produce two mature eggs, boosting pregnancy chances while…

This study tests whether testicular tissue frozen before puberty can be transplanted back into adult men who are infertile after cancer treatment. About 20 men who had gonadotoxic therapy as children and now have no sperm will receive their own stored tissue. Doctors will check i…

This early-stage study is testing a combination of herbs (Melats P) to see if it can help women with Polycystic Ovary Syndrome (PCOS) have regular periods and improve fertility. The study will include 116 women aged 18-40 with PCOS and insulin resistance. Researchers will track m…

This study tests whether treating eggs and sperm before fertilization can help people who have had complete failure with standard IVF or a previous ICSI cycle. Researchers will measure fertilization rates and embryo development. The goal is to improve the chance of pregnancy for …

This study tests whether a cheaper hormone drug (dydrogesterone) works as well as the standard drug (GnRH antagonist) to prevent early ovulation in women with low ovarian reserve who are undergoing two rounds of ovarian stimulation. 120 participants will be randomly assigned to o…

This study looks at whether having surgery to remove endometriosis from the bowel before IVF helps women with infertility get pregnant. About 120 women with painful, deep endometriosis will be randomly assigned to either surgery plus IVF or IVF alone. The main goal is to see whic…

This study compares two different doses of vaginal progesterone (600 mg vs 800 mg daily) to see if they work equally well in supporting pregnancy after a frozen embryo transfer. About 1020 women aged 18-50 undergoing hormone replacement therapy will participate. The goal is to fi…

This study is testing whether changing the timing of a common fertility treatment might help more people have babies. Researchers want to see if performing intrauterine insemination (IUI) 42 hours after an ovulation trigger shot works better than the standard 36-hour timing. They…

This study tests a new AI-assisted platform called IntelliWell to find rare sperm cells in testicular tissue from men with non-obstructive azoospermia, a condition where no sperm are found in semen. The platform analyzes tissue samples that standard methods say have no usable spe…

This study tests whether inhaling lavender essential oil for four weeks can improve mental health in 120 women waiting for IVF treatment. Participants are split into three groups: one gets real lavender, one gets a placebo scent, and one gets no scent. The goal is to see if aroma…

This study tests whether a newer sedative, remimazolam, combined with alfentanil, can lower the chance of low oxygen levels (hypoxia) during egg retrieval for IVF. About 400 women aged 18-50 will be randomly assigned to receive either remimazolam or the standard drug propofol. Th…

This study looks at two forms of vaginal progesterone (soft capsules vs. pessaries) used in frozen embryo transfer. It aims to see which one women find more satisfying, convenient, and tolerable. About 400 women will take part and share their experiences through online surveys. T…

This study compares two types of liquid used to transfer embryos during IVF. One liquid has a high amount of hyaluronic acid (a natural substance that helps cells stick), and the other has a low amount. Researchers want to see if the high-concentration liquid leads to more live b…

This study tests whether adding growth hormone and DHEA (a natural hormone) before IVF can increase the number of mature eggs in women with poor ovarian reserve. About 165 women will take one of these treatments for several weeks before their IVF cycle. The goal is to see which a…

This study tests whether pentoxyfilline, a drug that improves blood flow, can thicken the uterine lining and increase pregnancy rates in women with unexplained infertility who are using frozen embryos. About 100 women will receive the drug and be monitored for pregnancy. The goal…

This study tests whether warming the contrast dye used during a hysterosalpingogram (HSG) — a common fertility test — can reduce pain and prevent false blockages in the fallopian tubes. About 240 women aged 18–45 will be randomly assigned to receive either warm or room-temperatur…

This study tests whether atosiban, a drug that relaxes the uterus, can improve live birth rates in women who have had previous implantation failure and abnormal uterine contractions. About 792 women aged 20-40 will receive either atosiban or a placebo before a single embryo trans…

This study looks at whether collecting sperm after just one hour of abstinence (instead of the usual 2-5 days) results in embryos with normal chromosomes during IVF. About 187 couples with infertility will each provide sperm after both short and standard abstinence, and the embry…

This study looks at how infertility and fertility treatments like IVF affect women's sexual function and behavior. About 500 women under 45 with infertility will fill out an anonymous questionnaire about their sexual desire, satisfaction, and activities. The goal is to help docto…

This study aims to find genetic causes of inherited reproductive disorders, such as early or delayed puberty and infertility. Researchers will collect blood samples, medical histories, and smell tests from 850 participants with these conditions. No treatment is offered; the goal …

This study compares an AI system to doctors for deciding the optimal day to trigger ovulation in IVF. About 644 women undergoing ovarian stimulation will be randomly assigned to AI-guided or doctor-led monitoring. The goal is to see if the AI can achieve similar results in the nu…

This study looks at how searching the internet for health information affects stress and emotional well-being in women undergoing infertility treatment. About 200 women will fill out surveys about their online search habits, stress levels, and emotional health. The goal is to und…

This study looks at whether the level of a hormone called AMH in the fluid around a woman's eggs can help predict if an embryo is healthy (has the right number of chromosomes). Researchers will collect fluid from the first egg of each ovary during IVF in about 300 women aged 18-4…

This study follows 900 couples in Paris who tried preimplantation genetic testing (PGT) during IVF to prevent passing on severe genetic diseases, but did not have a baby from it. Researchers want to learn how many later have a child who lives to age 3 or older, and why some coupl…

This study looks at whether blood thinners (like aspirin or heparin) help the uterine lining prepare for pregnancy in women with infertility. About 300 women aged 20 to 45 will be watched using special ultrasound scans. The study does not give any treatment—it just observes what …

This study is testing whether an artificial intelligence tool can better predict outcomes for people undergoing in vitro fertilization (IVF) or other assisted reproductive treatments. Researchers will analyze data from 4,000 participants to see if the AI can accurately count eggs…

This study looks at how pesticides and the balance of bacteria in the gut and reproductive tract may affect infertility in women with endometriosis. Researchers will compare 160 women with and without endometriosis to find patterns that could lead to earlier diagnosis. The goal i…

This study looks at whether adding a hormone called LH to standard fertility drugs can improve hormone levels and egg quality in women over 35 who had a low number of eggs in a previous treatment. About 120 women will be randomly assigned to get either the standard drug alone or …

This study tests a new automated system (PRESERVE-CR) that freezes eggs and embryos during fertility treatments. Researchers want to see if the machine can match the success of skilled lab staff. About 125 patients will donate extra eggs or embryos that would otherwise be discard…

This study tests a new automated system called AURA that performs key steps in the IVF process, such as preparing sperm, finding eggs, and fertilizing them. About 150 people undergoing fertility treatment will have their eggs and sperm processed by the robot, while a few eggs are…

This study collects and stores ovarian tissue from females aged 4 to 35 who choose to freeze a sample before cancer treatment that could harm their fertility. Researchers will use a small portion of the tissue (no more than 20%) to study how ovaries work and what happens to ferti…

This study looks at how the bacteria and natural chemicals in couples' bodies might influence the success of IVF treatment. Researchers will collect samples from 1000 couples to see if these factors are linked to pregnancy, miscarriage, or live birth. The goal is to better unders…

This study explores how natural contractions of the uterus (called endometrial peristalsis) influence pregnancy rates in frozen embryo transfer. Researchers will track 356 women aged 18-42 to see if different hormone preparation protocols change these contractions and affect embr…

This study looks at whether low levels of a protein called mannose-binding lectin (MBL) in the blood are linked to repeated pregnancy loss or failed embryo transfers. Researchers will compare 500 women with these issues to a general population group. The goal is to understand if …

This study tests whether artificial intelligence can analyze routine vaginal ultrasound images of the uterine lining to predict whether an embryo will implant during IVF. About 1,500 women aged 18–40 undergoing IVF will participate, with no extra visits or procedures. The goal is…

This study will follow about 2,500 Chinese women who are using the fertility drug REKOVELLE for the first time during IVF or ICSI treatments. Researchers want to see how well the drug works in everyday medical practice, including live birth rates and safety. The study does not te…

This study tests whether a patient navigator—a guide who helps with appointments, insurance, and paperwork—can speed up infertility care for underserved patients at Boston Medical Center. About 40 people will receive navigator help, and their progress will be compared to similar …