INFERTILITY

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can increase the chance of having a baby after a specific type of IVF (ICSI). The trial involves 366 women under 37 and their partners. The main goal is to see if cpFT leads to mor…

This study tests whether a new device called SwimCount Harvester can prepare sperm as well as or better than current methods for couples doing IVF with genetic testing. About 1,600 couples will take part, with the female partner aged 21-45 and the male partner 21 or older. The go…

This study tests whether injecting platelet-rich plasma (PRP) into the lining of the womb or infusing it into the womb works better for women who have had repeated failed embryo transfers. 180 women aged 18-40 with a history of at least two failed transfers will be randomly assig…

This study tests two treatments—isotretinoin (an acne medication) and hCG (a hormone therapy)—to see which better helps men with low or no sperm count produce moving sperm. About 100 men aged 19 to 50 will take one treatment for three months. The goal is to find new options for m…

This study tests whether a progesterone injection works as well as a vaginal gel for helping embryos implant and maintain early pregnancy after frozen embryo transfer. About 680 women aged 35 to 42 with infertility will receive either the injection or the gel, and researchers wil…

This study tests whether group preconception care, adapted from group prenatal care, can improve pregnancy and newborn outcomes for fertility patients. About 140 couples at Penn Fertility Care will be randomly assigned to either group virtual sessions or usual care. Researchers w…

This pilot study tests whether an internet-based stress management program called Stress Free Now can lower stress and increase pregnancy rates in women aged 18-34 who have been trying to conceive for 6-12 months. Forty women will be randomly assigned to the program or a waitlist…

This study follows 1,500 Asian women using REKOVELLE for their first ovarian stimulation treatment as part of IVF or ICSI. Researchers track how many women have a live baby within 12 months and how the drug is used in everyday practice. The goal is to understand real-world effect…

This study looks at how the process of diagnosing infertility affects the sex lives of couples. Researchers will follow 80 heterosexual couples at a French hospital, asking them to fill out questionnaires about their sexual function, satisfaction, and body image. The goal is to u…

This study looks at an AI software called MAGENTA BLAST that helps predict which early-stage embryos (Day 3) will grow into blastocysts (Day 5) during IVF. Researchers reviewed data from 80 women to see if the AI tool improves prediction accuracy. The goal is to give doctors bett…

This study tests whether a program that sends educational texts and videos can help people complete their fertility workup more quickly. About 160 new female patients at Penn Fertility Care will be randomly assigned to get the program or standard care. The goal is to see if the p…

This study was designed to measure how a hormone called GnRH moves through the body when given through a small pump (OmniPod) in healthy women. The goal was to help develop a treatment for women who miss their periods due to low GnRH. However, the study was withdrawn before any p…

This study looks at how obesity may cause fertility problems by disrupting hormones that control the menstrual cycle. Researchers will measure hormone levels and insulin response in 84 women with regular cycles. The goal is to understand the link between obesity and infertility t…

This study looks at 2000 IVF patients to see if time-lapse videos of embryos can reveal clues about their genetic health. Researchers will compare the videos with genetic test results to find patterns. The goal is to learn more, not to provide a treatment.