INFERTILITY

This study tests whether injecting a woman's own platelet-rich plasma (PRP) into the ovary can help restore function in women with premature ovarian insufficiency (early menopause). 35 women under 40 will receive PRP in one ovary and a saline placebo in the other. The main goal i…

This Phase 3 trial tests whether taking Elagolix, a hormone-blocking drug, before IVF can increase live birth rates in women with endometriosis. About 97 women will receive either Elagolix or a placebo before their IVF cycle. The goal is to see if this pre-treatment improves the …

This study tests whether a progesterone shot under the skin works as well as a vaginal gel for supporting early pregnancy after a frozen embryo transfer. About 688 women aged 35 to 42 with infertility will take part. The goal is to see which method leads to more successful pregna…

This study tests two treatments—isotretinoin (an acne medication) and hCG (a hormone)—to see if they can help men with low or no sperm count produce moving sperm. About 100 men aged 19 to 50 will take one of the drugs for three months. The goal is to find new options for male inf…

This study tests whether platelet-rich plasma (PRP), made from a woman's own blood, can improve pregnancy rates in those who have had multiple failed embryo transfers. 180 women will receive PRP either as an injection into the uterus lining or as a simple infusion, and their outc…

This study compares a new microfluidic device, SwimCount Harvester, to standard sperm preparation methods in couples undergoing IVF with genetic testing (PGT-A). About 1,600 couples will be randomly assigned to one of the two methods. The goal is to see if the device leads to mor…

This pilot study tests whether an online stress management program called Stress Free Now can lower stress and possibly increase pregnancy rates in women aged 18-34 who have been trying to conceive for 6-12 months. Forty women will be randomly assigned to either the program or a …

This study tests whether music therapy can reduce anxiety and improve pregnancy rates in women receiving artificial insemination. Researchers will compare pregnancy outcomes in 254 women who receive standard care plus music therapy versus standard care alone. The goal is to see i…

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can increase the number of live births in women under 37 who are having a type of IVF called ICSI. About 366 couples took part. The goal is to see if this simple change can improve…

This study planned to check whether vitamin D levels affect pregnancy rates in women undergoing IVF. It was withdrawn before enrolling any participants, so no data or conclusions are available. The idea was to measure vitamin D in blood samples and compare it to IVF outcomes like…

This study looks at whether transferring a frozen embryo on day 6 or day 7 of progesterone treatment leads to more live births. It includes 316 women aged 18-43 who have at least one high-quality, genetically normal embryo. Researchers will track pregnancy and miscarriage rates t…

This study tests a patient navigator program for 28 underserved people struggling with infertility. The navigator helps with insurance, appointments, and tests to speed up care. Researchers compare their progress to similar patients from the year before. The goal is to see if thi…

This study tests whether a benchtop incubator helps more embryos reach the blastocyst stage compared to a standard box incubator in people undergoing IVF. 252 participants will have their eggs split and placed in both incubators. The goal is to see which device supports better em…

This study investigates how obesity-related factors like high insulin and fat levels may disrupt fertility in women. Researchers will measure hormone changes and metabolic responses in 84 women. The goal is to understand the underlying causes and inform future treatments to impro…

This study follows 1,500 Asian women using REKOVELLE for the first time during IVF to see how well it works in everyday medical practice. Researchers will track live birth rates and how the drug is used. The goal is to understand its real-world effectiveness and safety for this s…

This study watches embryos grow using time-lapse cameras and compares their development to genetic test results. Researchers hope to find visual clues that indicate a healthy embryo. 2000 IVF patients are taking part. If a link is found, it could lead to a less invasive way to ch…

This study tests a text-messaging program that sends reminders and educational videos to people starting fertility testing. The goal is to see if it helps them complete all the required tests faster. About 160 new female patients at Penn Fertility Care will take part, and half wi…

This study explores whether a woman's pain threshold, measured before the procedure, can predict how much anesthesia she will need during egg retrieval for IVF. Researchers will measure pain thresholds in 30 women and track the amount of sedatives they use. The goal is to persona…

This study looks at how the process of diagnosing infertility affects the sexuality of couples. Researchers will survey 80 heterosexual couples to see if the diagnosis and testing cause sexual problems. The goal is to better understand the link between infertility and sexual heal…

This study was designed to see how a hormone called GnRH is processed by the body when given through a small pump (OmniPod) instead of a needle. It was meant for healthy women aged 18 to 40 with regular periods. However, the trial was withdrawn before any participants were enroll…

This study tests whether group virtual preconception care can improve pregnancy and health outcomes for people with infertility. About 140 patients from Penn Fertility Care will either join biweekly group sessions or receive usual care. Researchers will track blood pressure, weig…