Can acne drug or hormone shots help men with low sperm count?

NCT ID NCT07481370

ENROLLING_BY_INVITATION Disease control Sponsor: University of Nebraska Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two treatments—isotretinoin (an acne medication) and hCG (a hormone)—to see if they can help men with low or no sperm count produce moving sperm. About 100 men aged 19 to 50 will take one of the drugs for three months. The goal is to find new options for male infertility when standard treatments don't work.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: isotretinoin and human chorionic gonadotropin (hCG)
What this could lead to: If successful, this could point toward a new treatment option for men with infertility due to low or absent sperm production.
What could go wrong: This is a small, early-phase study with only 100 participants. The treatments may not improve sperm production, and side effects from the medications are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for AZOOSPERMIA, NONOBSTRUCTIVE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

azoospermia hypogonadotropic hypogonadism infertility disorder oligospermia spermatogenic failure 3 spermatogenic failure, Y-linked, 2

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AZOOSPERMIA, NONOBSTRUCTIVE INFERTILITY OLIGOSPERMIA

Contacts and locations

Locations

University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.