Can acne drug or hormone shots help men with low sperm count?
NCT ID NCT07481370
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two treatments—isotretinoin (an acne medication) and hCG (a hormone)—to see if they can help men with low or no sperm count produce moving sperm. About 100 men aged 19 to 50 will take one of the drugs for three months. The goal is to find new options for male infertility when standard treatments don't work.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
isotretinoin and human chorionic gonadotropin (hCG)
What this could lead to
If successful, this could point toward a new treatment option for men with infertility due to low or absent sperm production.
What could go wrong
This is a small, early-phase study with only 100 participants. The treatments may not improve sperm production, and side effects from the medications are possible.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States