Azoospermia

This trial tests whether injecting a man's own purified stem cells into his testicles can restart sperm production. It is for men with non-obstructive azoospermia, a condition where the testicles produce little or no sperm. The stem cells are taken from the patient's bone marrow,…

This study tests a gel called PKB171, which contains a drug used to improve blood flow and sperm movement. Couples with mild male infertility who have been trying to conceive for 6 to 24 months apply the gel after sex. The goal is to see if it increases pregnancy rates compared t…

This study tests whether Fertilo, a new solution for maturing eggs outside the body, works better than the current standard (MediCult IVM) for women aged 18-35 undergoing IVF. About 500 participants will have their eggs treated with either Fertilo or MediCult, and researchers wil…

This study tests whether adding a hormone drug called Decapeptyl to standard IVF treatments can increase the number of live births. About 784 women under 43 with subfertility will receive either the drug or a placebo during egg retrieval and embryo transfer. The goal is to see if…

This study tests whether a cheaper hormone (dydrogesterone) works as well as a standard drug (GnRH antagonist) to prevent early ovulation in women with low ovarian response undergoing double ovarian stimulation. About 120 women will be randomly assigned to one of the two treatmen…

This phase 3 trial compares two ways to prepare the womb lining for a frozen embryo transfer: a modified natural cycle using progesterone only, versus standard hormone replacement therapy. The study will enroll 336 women aged 21-44 with regular cycles to see which method leads to…

This pilot study tests whether transplanting a man's own frozen testicular tissue, stored before childhood cancer treatment, can restore fertility. Twenty men with azoospermia (no sperm) who want children will undergo the procedure. Doctors will check if the graft produces sperm …

This study tests whether a probiotic called Fertibiome can help restore a healthy balance of bacteria in the vagina for women or couples having trouble getting pregnant. About 120 participants will take either the probiotic or a placebo for up to 6 months. The goal is to see if t…

This study tests whether using special devices during embryo transfer can help more IVF patients get pregnant. The devices keep the embryo at the right temperature and control the transfer process to reduce human error. About 160 women having frozen embryo transfers will be rando…

This Phase 2 trial is testing whether a fixed dose of the hormone follitropin delta (Rekovelle) can improve ovarian stimulation for intrauterine insemination (IUI) in women with regular cycles. The goal is to promote the growth of two mature eggs per cycle to increase pregnancy c…

This phase 3 trial tests whether a lower daily dose (600 mg) of vaginal progesterone works as well as the standard dose (800 mg) for supporting pregnancy after a frozen embryo transfer. About 1,020 women undergoing IVF will be randomly assigned to one of the two doses. The main g…

This Stanford study tests whether injecting a man's own platelet-rich plasma (PRP) into his testicles can help produce sperm. Ten men with nonobstructive azoospermia who previously failed sperm retrieval will receive the injection. Three months later, doctors will check for sperm…

This study tests whether treating eggs and sperm before fertilization can help people who have had complete failure with standard IVF or one prior ICSI cycle. Researchers will measure fertilization rates and embryo development. The goal is to improve chances of pregnancy for thos…

This study tests whether round spermatids (immature sperm cells) can be used in IVF to help men with a condition called non-obstructive azoospermia, where no mature sperm are present. Researchers will collect these cells from the testicles and inject them into eggs to see if they…

This study tests whether atosiban, a drug that relaxes the womb, can improve live birth rates in women who have had previous IVF failures and have abnormal womb contractions. About 792 women aged 20-40 will receive either atosiban or a placebo before a single embryo transfer. The…

This study compares two embryo transfer liquids—one with a high amount of hyaluronic acid (a natural 'sticky' substance) and one with a low amount—to see which leads to more live births. About 858 women having a single embryo transfer will take part. The goal is to find out if th…

This study tests a new ultra-rapid freezing method for embryos (blastocysts) in women receiving donor eggs. The goal is to see if this faster approach is as safe and effective as the standard freezing method. Researchers will compare how many embryos survive thawing and how many …

This study tests a new AI-assisted platform called IntelliWell to find rare sperm cells in testicular tissue from men with non-obstructive azoospermia, a condition where standard analysis finds no sperm. The platform processes tissue that would otherwise be discarded, and if sper…

This pilot study uses a special ultrasound technique called shear wave elastography to measure how stiff the uterus, cervix, and ovaries are in women with and without fertility problems. Researchers will track changes across the menstrual cycle in 40 women to establish normal ran…

This study follows 900 couples in Paris who tried preimplantation genetic diagnosis (PGD) to avoid passing on a severe genetic disease but did not have a baby from it. Researchers want to know how many later have a healthy child naturally, through other treatments, or decide to s…

This study compares two sperm collection timings—1 hour versus the usual 2-5 days of abstinence—to see which leads to more embryos with normal chromosomes during IVF. Researchers will track embryo health and pregnancy rates in 187 women. The goal is to find a simple way to improv…

This study looks at male factors that influence a couple's chance of getting pregnant. Researchers will compare fertile and subfertile couples to create a fertility index that combines male and female factors to predict pregnancy. The goal is to better understand male reproductiv…

This observational study aims to understand how the CFTR gene is regulated in epididymal cells, which may help explain male infertility linked to cystic fibrosis. Researchers will collect leftover tissue samples from 20 men already scheduled for surgery. No extra procedures are n…

This study aims to find genes that may cause infertility in people with non-obstructive azoospermia (low or no sperm) or primary ovarian insufficiency (early menopause). Researchers will collect saliva samples from 500 adults to look for genetic differences. No new treatments are…

This study tests a new lab technique called HyperSperm to see if it can make sperm move better and stay healthy. Researchers will collect semen samples from 300 men with different fertility issues and compare the new method to the standard one. The goal is to find a safer and mor…

This study is testing a new test called the Aurora test, which uses cells that normally surround the egg (cumulus cells) to help select the best embryo for transfer in IVF. The test is non-invasive and aims to improve pregnancy and live birth rates compared to the standard method…

This study will follow 2,500 Chinese women who are prescribed REKOVELLE for the first time during IVF or ICSI treatments. Researchers will track how the drug is used in routine practice, its effectiveness (including live birth rates), and any side effects. The goal is to understa…

This study is testing whether an artificial intelligence tool can analyze 3D ultrasound images of the ovaries to better predict how well a woman will respond to fertility treatments like IVF. Researchers will enroll about 4,000 patients undergoing ovarian stimulation. The goal is…

This study tests whether a new automated system can freeze human eggs and embryos as effectively as the current manual method. Researchers will compare survival rates after thawing between the two methods using surplus eggs and embryos from 125 IVF patients. If successful, automa…

This study looks at whether levels of Anti-Müllerian hormone (AMH) in the fluid around a woman's eggs can predict if an embryo has the right number of chromosomes. Researchers will collect fluid from one follicle in each ovary during egg retrieval in 300 women undergoing IVF. The…

This study looks at whether doing a laser-assisted hatching procedure on Day 3 or Day 5 of embryo growth changes the genetic test results in IVF. About 200 people having IVF with genetic testing will take part. The goal is to see if timing affects embryo health and the accuracy o…