Could a Man's own stem cells restore his fertility?

NCT ID NCT02641769

Recruiting now Disease control Sponsor: Stem Cells Arabia Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This trial tests whether injecting a man's own purified stem cells into his testicles can restart sperm production. It is for men with non-obstructive azoospermia, a condition where the testicles produce little or no sperm. The stem cells are taken from the patient's bone marrow, purified, and then injected directly into the seminiferous tubules. The study will follow participants for 24 months to check for sperm in semen or testicular tissue and to monitor safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: autologous bone marrow-derived stem cells (spermatogonial and mesenchymal)
What this could lead to: If successful, this approach could help men with certain types of infertility produce their own sperm, potentially enabling biological fatherhood without donor sperm.
What could go wrong: This is an early-phase study (Phase 1/2) with 600 participants, so results are not yet proven. Risks include infection, bleeding, or failure to produce viable sperm.

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Conditions

The condition(s) this trial relates to.

azoospermia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-OBSTRUCTIVE AZOOSPERMIA

Contacts and locations

Locations

Stem Cells of Arabia
RECRUITING

Amman, Amman Governorate, 11953, Jordan

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