Could two existing drugs unlock sperm production in infertile men?

NCT ID NCT06706414

Ongoing Disease control Sponsor: Martin Blomberg Jensen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study tests whether two drugs—denosumab and letrozole—can help men with a specific type of infertility (non-obstructive azoospermia) start producing sperm. Sixteen men will take the drugs for about three months, and researchers will check for sperm in their semen or testicular tissue. The goal is to see if this combination can improve fertility, but it's a small, early trial, so results are uncertain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Denosumab (Prolia) injection and letrozole oral tablet
What this could lead to: If it works, this could offer a new way to help some infertile men produce sperm, potentially enabling biological fatherhood.
What could go wrong: This is a very small, early-phase trial with only 16 men. It may not work for everyone, and the long-term safety and effectiveness are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

azoospermia male infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFERTILITY, MALE

Contacts and locations

Locations

Division of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Herlev and Gentofte Hospital

Herlev, 2730, Denmark

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