Could a weekly pill help men with no sperm become fathers?

NCT ID NCT07571928

Not yet recruiting Disease control Sponsor: Martin Blomberg Jensen Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study tests a drug called leflutrozole in 15 men who have no sperm in their semen due to a blockage-free cause. The drug is taken as a weekly capsule and aims to boost sperm production. Researchers will check if sperm appear in the semen after 12-20 weeks of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: leflutrozole (a drug that blocks estrogen production)
What this could lead to: If it works, this could point toward a new treatment for some men with infertility due to low sperm production.
What could go wrong: This is a very early, small trial with only 15 men. It may not work, and the drug could have side effects. Success is far from guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

azoospermia male infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFERTILITY DUE TO AZOOSPERMIA INFERTILITY, MALE

Contacts and locations

Locations

Division of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Copenhagen University Hospital Herlev., Herlev,

Herlev, 2100, Denmark

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