New gel could boost fertility for couples struggling to conceive
NCT ID NCT07669584
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a gel called PKB171, which contains a drug used to improve blood flow and sperm movement. Couples with mild male infertility who have been trying to conceive for 6 to 24 months apply the gel after sex. The goal is to see if it increases pregnancy rates compared to a placebo gel. The trial involves 732 couples across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pentoxifylline gel (PKB171)
- What this could lead to
- If it works, this gel could offer a simple, at-home option to improve pregnancy rates for couples with mild male factor infertility.
- What could go wrong
- This is an early combined phase 2/3 trial. A prior phase 2 was stopped early due to recruitment issues, and the main side effects include local irritation. Success is not guaranteed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Assir Dreta-Cap Pare Claret
NOT_YET_RECRUITINGBarcelona, 08037, Spain
-
Assir Dreta-Cap Roger de Flor
NOT_YET_RECRUITINGBarcelona, 08037, Spain
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Clinica Fertty
NOT_YET_RECRUITINGBarcelona, 08010, Spain
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Clinica Sagrada Familia
RECRUITINGBarcelona, 08022, Spain
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Clinica Universidad de Navarra
RECRUITINGPamplona, Navarre, 31008, Spain
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Clinica Universidad de Navarra
RECRUITINGMadrid, 28027, Spain
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HM Gabinete Médico Velázquez
NOT_YET_RECRUITINGMadrid, 28001, Spain
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Hospital Universitario L Paz
NOT_YET_RECRUITINGMadrid, 28046, Spain
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Hospital Universitario Nuestra Señora de Valme
RECRUITINGSeville, 41014, Spain
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Hospital Universitario San Rafael
RECRUITINGMadrid, 28016, Spain
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Hospital de la Santa Creu i Sant Pau
NOT_YET_RECRUITINGBarcelona, 08041, Spain
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Hospital del Mar
RECRUITINGBarcelona, 08003, Spain
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