Male infertility

This trial tests whether injecting a man's own purified stem cells into his testicles can restart sperm production. It is for men with non-obstructive azoospermia, a condition where the testicles produce little or no sperm. The stem cells are taken from the patient's bone marrow,…

This study tests a gel called PKB171, which contains a drug used to improve blood flow and sperm movement. Couples with mild male infertility who have been trying to conceive for 6 to 24 months apply the gel after sex. The goal is to see if it increases pregnancy rates compared t…

This study tests whether a single midline incision in the pubic area works as well as the standard two incisions (one on each side) for repairing varicoceles in both testicles. The trial enrolls men aged 18 to 45 with a palpable bilateral varicocele and infertility lasting at lea…

This study tests whether Fertilo, a new solution for maturing eggs outside the body, works better than the current standard (MediCult IVM) for women aged 18-35 undergoing IVF. About 500 participants will have their eggs treated with either Fertilo or MediCult, and researchers wil…

This study tests whether adding a hormone drug called Decapeptyl to standard IVF treatments can increase the number of live births. About 784 women under 43 with subfertility will receive either the drug or a placebo during egg retrieval and embryo transfer. The goal is to see if…

This study tests whether a cheaper hormone (dydrogesterone) works as well as a standard drug (GnRH antagonist) to prevent early ovulation in women with low ovarian response undergoing double ovarian stimulation. About 120 women will be randomly assigned to one of the two treatmen…

This phase 3 trial compares two ways to prepare the womb lining for a frozen embryo transfer: a modified natural cycle using progesterone only, versus standard hormone replacement therapy. The study will enroll 336 women aged 21-44 with regular cycles to see which method leads to…

This study tests a new way to help men who lost fertility due to cancer or autoimmune treatments. Doctors will transplant the patient's own frozen testicular tissue back into them. The goal is to see if it is safe and can restart sperm production.

This pilot study tests whether transplanting a man's own frozen testicular tissue, stored before childhood cancer treatment, can restore fertility. Twenty men with azoospermia (no sperm) who want children will undergo the procedure. Doctors will check if the graft produces sperm …

This study tests whether a probiotic called Fertibiome can help restore a healthy balance of bacteria in the vagina for women or couples having trouble getting pregnant. About 120 participants will take either the probiotic or a placebo for up to 6 months. The goal is to see if t…

This study tests whether using special devices during embryo transfer can help more IVF patients get pregnant. The devices keep the embryo at the right temperature and control the transfer process to reduce human error. About 160 women having frozen embryo transfers will be rando…

This study tests whether a strict low-carbohydrate diet combined with lifestyle guidance can help obese men (BMI 30+) lose weight and improve their fertility. Researchers will track weight, semen quality, and reproductive outcomes in 98 men aged 22-40. The goal is to find a non-d…

This Phase 2 trial is testing whether a fixed dose of the hormone follitropin delta (Rekovelle) can improve ovarian stimulation for intrauterine insemination (IUI) in women with regular cycles. The goal is to promote the growth of two mature eggs per cycle to increase pregnancy c…

This phase 3 trial tests whether a lower daily dose (600 mg) of vaginal progesterone works as well as the standard dose (800 mg) for supporting pregnancy after a frozen embryo transfer. About 1,020 women undergoing IVF will be randomly assigned to one of the two doses. The main g…

This study looks at whether drinking a daily serving of gazpacho, a cold tomato-based soup, can improve semen quality in men with low sperm counts or poor sperm movement. Eighty men will follow a Mediterranean diet for 12 weeks, with half also drinking gazpacho each day. Research…

This study compares two IVF methods for couples where the male partner has severe sperm shape issues (teratospermia). One group gets standard ICSI (sperm injected into egg), the other gets ICSI plus a chemical boost to activate the egg. The goal is to see which leads to more live…

This study is testing a new device called Plan A that blocks sperm from passing through the vas deferens, similar to a vasectomy, but designed to be reversed later. Forty healthy men aged 25 to 65 will receive the device and be monitored for safety and effectiveness. The goal is …

This study tests whether taking probiotics daily for about 100 days can improve sperm count, movement, and shape in men with infertility. Sixty men aged 20 to 45 will be randomly assigned to receive either probiotics or a placebo. Researchers will measure sperm quality at the sta…

This Stanford study tests whether injecting a man's own platelet-rich plasma (PRP) into his testicles can help produce sperm. Ten men with nonobstructive azoospermia who previously failed sperm retrieval will receive the injection. Three months later, doctors will check for sperm…

This study tests whether treating eggs and sperm before fertilization can help people who have had complete failure with standard IVF or one prior ICSI cycle. Researchers will measure fertilization rates and embryo development. The goal is to improve chances of pregnancy for thos…

This study tests whether round spermatids (immature sperm cells) can be used in IVF to help men with a condition called non-obstructive azoospermia, where no mature sperm are present. Researchers will collect these cells from the testicles and inject them into eggs to see if they…

This early-stage study is testing a new drug called STSP-0902 to see if it is safe for men. It includes healthy volunteers and men with low sperm count or low sperm movement. The main goal is to check for side effects and how the drug moves through the body. This is a first step …

This study explores whether hyperbaric oxygen therapy (HBOT) can help men with low sperm count (oligospermia) improve their fertility. Researchers will measure changes in sperm count, shape, and movement in 15 participants. The goal is to see if HBOT offers a new, non-drug option…

This study tests a medicine called probenecid to see if it can improve sperm movement in men with spinal cord injury. Many of these men have normal sperm counts, but their sperm don't swim well, causing infertility. The trial will enroll 90 men and measure changes in sperm qualit…

This study tests whether atosiban, a drug that relaxes the womb, can improve live birth rates in women who have had previous IVF failures and have abnormal womb contractions. About 792 women aged 20-40 will receive either atosiban or a placebo before a single embryo transfer. The…

This study compares two embryo transfer liquids—one with a high amount of hyaluronic acid (a natural 'sticky' substance) and one with a low amount—to see which leads to more live births. About 858 women having a single embryo transfer will take part. The goal is to find out if th…

This study tests a new ultra-rapid freezing method for embryos (blastocysts) in women receiving donor eggs. The goal is to see if this faster approach is as safe and effective as the standard freezing method. Researchers will compare how many embryos survive thawing and how many …

This study tests a new AI-assisted platform called IntelliWell to find rare sperm cells in testicular tissue from men with non-obstructive azoospermia, a condition where standard analysis finds no sperm. The platform processes tissue that would otherwise be discarded, and if sper…

This study is developing an artificial intelligence (AI) platform to analyze sperm samples and predict how likely they are to lead to a successful pregnancy during IVF. Researchers will collect and study 500 semen samples from men undergoing IVF, using AI to look for patterns tha…

This study is creating a biobank of male biological samples, such as sperm and testicular tissue, from men undergoing fertility treatments. The goal is to collect and store these samples for future research on male infertility and assisted reproductive technologies. Up to 1,000 p…

This pilot study uses a special ultrasound technique called shear wave elastography to measure how stiff the uterus, cervix, and ovaries are in women with and without fertility problems. Researchers will track changes across the menstrual cycle in 40 women to establish normal ran…

This study is testing a new technique called diamond magnetometry to measure free radicals in individual sperm cells and blood. Free radicals are natural but can damage sperm if out of balance. Researchers will also look at the bacteria in semen and how lifestyle and diet affect …

This study looks at whether a short diet change can improve sperm quality in men whose partners are undergoing IVF. One hundred couples in Sweden will take part. Men will follow Nordic dietary guidelines for a few weeks. Researchers will check sperm count, movement, and small RNA…

This study follows 900 couples in Paris who tried preimplantation genetic diagnosis (PGD) to avoid passing on a severe genetic disease but did not have a baby from it. Researchers want to know how many later have a healthy child naturally, through other treatments, or decide to s…

This study surveys 400 men undergoing ICSI due to low sperm quality. Researchers want to understand their emotional experiences, social burden, and testosterone levels, and compare results to a similar study from 2008. The goal is to see if men's needs in fertility care have chan…

This study compares two sperm collection timings—1 hour versus the usual 2-5 days of abstinence—to see which leads to more embryos with normal chromosomes during IVF. Researchers will track embryo health and pregnancy rates in 187 women. The goal is to find a simple way to improv…

This observational study aims to identify and classify Traditional Medicine (TM) syndromes in men aged 18 to 60 with male infertility and oligoasthenoteratozoospermia (OAT) syndrome. Researchers will first review TM literature to list symptoms, then survey 300 participants and us…

This study looks at male factors that influence a couple's chance of getting pregnant. Researchers will compare fertile and subfertile couples to create a fertility index that combines male and female factors to predict pregnancy. The goal is to better understand male reproductiv…

This observational study aims to understand how the CFTR gene is regulated in epididymal cells, which may help explain male infertility linked to cystic fibrosis. Researchers will collect leftover tissue samples from 20 men already scheduled for surgery. No extra procedures are n…

This study aims to find genes that may cause infertility in people with non-obstructive azoospermia (low or no sperm) or primary ovarian insufficiency (early menopause). Researchers will collect saliva samples from 500 adults to look for genetic differences. No new treatments are…

This study tests a new lab technique called HyperSperm to see if it can make sperm move better and stay healthy. Researchers will collect semen samples from 300 men with different fertility issues and compare the new method to the standard one. The goal is to find a safer and mor…

This study is testing a new test called the Aurora test, which uses cells that normally surround the egg (cumulus cells) to help select the best embryo for transfer in IVF. The test is non-invasive and aims to improve pregnancy and live birth rates compared to the standard method…

This study will follow 2,500 Chinese women who are prescribed REKOVELLE for the first time during IVF or ICSI treatments. Researchers will track how the drug is used in routine practice, its effectiveness (including live birth rates), and any side effects. The goal is to understa…

This study is testing whether an artificial intelligence tool can analyze 3D ultrasound images of the ovaries to better predict how well a woman will respond to fertility treatments like IVF. Researchers will enroll about 4,000 patients undergoing ovarian stimulation. The goal is…

This study tests whether a new automated system can freeze human eggs and embryos as effectively as the current manual method. Researchers will compare survival rates after thawing between the two methods using surplus eggs and embryos from 125 IVF patients. If successful, automa…

This study looks at whether levels of Anti-Müllerian hormone (AMH) in the fluid around a woman's eggs can predict if an embryo has the right number of chromosomes. Researchers will collect fluid from one follicle in each ovary during egg retrieval in 300 women undergoing IVF. The…

This study looks at whether doing a laser-assisted hatching procedure on Day 3 or Day 5 of embryo growth changes the genetic test results in IVF. About 200 people having IVF with genetic testing will take part. The goal is to see if timing affects embryo health and the accuracy o…