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Mitochondrial DNA mutation may be a hidden cause of male infertility

NCT ID NCT07691827

Recruiting now Knowledge-focused Sponsor: The Third Affiliated Hospital of Guangzhou Medical University Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study investigates whether a specific mitochondrial DNA variant (MT-ND1 m.3700G>A) is associated with severe male infertility, specifically conditions where sperm production is absent or extremely low. Researchers analyzed existing medical records and biological samples from affected men, their family members, and fertile controls to see if the variant is inherited from the mother and linked to infertility. No treatments or interventions were given; the goal is to better understand the genetic causes of these infertility conditions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If confirmed, this could point toward genetic screening or future therapies for some forms of male infertility.
What could go wrong
This is an observational study, not a treatment trial. The findings may not apply to other populations or explain all cases of infertility.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

azoospermia male infertility oligospermia spermatogenic failure 3 spermatogenic failure, Y-linked, 2

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AZOOSPERMIA, NONOBSTRUCTIVE CRYPTOZOOSPERMIA

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The Third Affiliated Hospital of Guangzhou Medical University

    RECRUITING

    Guangzhou, Guangdong, 510150, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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