Hormone shots may help infertile men avoid surgery
NCT ID NCT07540611
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving men with low testosterone and no sperm in their ejaculate a combination of two hormones (hCG and FSH) can help them produce usable sperm for IVF. About 860 men will either receive the hormone therapy or standard care for 16 weeks. The goal is to see if the treatment increases the chance of finding sperm, either in the ejaculate or through a minor surgical procedure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hCG (human chorionic gonadotropin) and FSH (follicle-stimulating hormone) injections, plus optional aromatase inhibitors (anastrozole or letrozole)
What this could lead to
If it works, this could offer a non-surgical way to obtain sperm for IVF in men with low testosterone and no sperm in their ejaculate.
What could go wrong
This is an early-stage trial with 860 participants, and the treatment may not increase sperm production. Hormone therapy can cause side effects like mood changes or injection-site reactions.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Recruitment
Patna, Bihar, 800014, India
Contact Phone: •••-•••-••••
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Recruitment
Bangalore, Karnataka, 560041, India
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Recruitment
Bhāndup, Maharashtra, India
Contact Phone: •••-•••-••••
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Recruitment
Pune, Maharashtra, India
Contact
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Recruitment
Delhi, National Capital Territory of Delhi, India
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Recruitment
Jaipur, Rajasthan, India
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Recruitment
Allahābād, Uttar Pradesh, India
Contact
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Recruitment
Lucknow, Uttar Pradesh, India
Contact