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Sperm protein could be key to unlocking male infertility

NCT ID NCT07684339

Knowledge-focused Sponsor: Fakih IVF Fertility Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study looks at whether levels of a sperm protein called PLCZeta are linked to semen quality and fertility outcomes. Researchers will measure PLCZeta in sperm samples from couples undergoing IVF or routine semen analysis. The goal is to see if low or abnormal PLCZeta predicts lower pregnancy or live birth rates. This is an observational study, so no treatment is given.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If PLCZeta proves to be a reliable marker, it could help diagnose male infertility and guide treatment choices in IVF.
What could go wrong
This is an observational study, not a treatment trial. It may not find a clear link, and results may not apply to all fertility cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Male partners in couples suffering from infertility and seeking IVF treatment at the FAKIH IVF clinics in the UAE.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Couple inclusion criteria: * Presenting to the IVF clinic for IVF/ICSI treatment or routine semen analysis * Semen sample must have a total sperm count of ≥1 million sperm/ml * Availability of excess, leftover sperm after clinical treatment procedures * Couples must have experienced infertility for at least one year and be undergoing fertility treatment * Undergoing standard clinical treatment protocols (including embryo culture and, when applicable, PGTA) with routinely collected treatment outcome data * Sufficient ovarian reserve and/or meeting the clinic's standard criteria for fertility treatment Couple exclusion criteria: * Known genetic disorders affecting fertility * History of vasectomy or other irreversible sterilization procedures * Current use of medications known to affect sperm parameters (e.g., exogenous androgens, chemotherapeutic agents, or other drugs specifically impacting spermatogenesis) * Recent history of chemotherapy or radiation therapy * Female age \>38 years old * Known chromosomal abnormalities or genetic disorders that directly affect oocyte quality or embryo development * Presence of severe uterine or pelvic pathology (e.g., significant uterine anomalies, advanced endometriosis) * Documented ovarian failure or extremely diminished ovarian reserve as determined by AMH levels (AMH \>1 ng/mL, AFC ≥5) * Use of medications or undergoing treatments that could significantly alter oocyte quality or embryogenesis (outside standard ART protocols).

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Conditions

The condition(s) this trial relates to.

male infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Male infertility Male subfertility

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fakih IVF

    RECRUITING

    Abu Dhabi, United Arab Emirates

  • Khalifa University

    ACTIVE_NOT_RECRUITING

    Abu Dhabi, United Arab Emirates

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