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Surgery for enlarged scrotum veins may boost sperm health by reducing immature cells

NCT ID NCT07684963

Disease control Sponsor: Assiut University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study looks at how surgery to fix varicocele—enlarged veins in the scrotum—affects the number of immature sperm cells in semen. Infertile men aged 20 to 45 with varicocele will have a microsurgical procedure to tie off the abnormal veins. Their semen will be tested before surgery and again at 3 and 6 months after to see if the surgery improves sperm quality and reduces immature cells.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Subinguinal microsurgical varicocelectomy
What this could lead to
If successful, this study could help doctors better predict fertility improvements after varicocele surgery by tracking immature sperm cells.
What could go wrong
This is a small, early-stage study with only 40 participants, so results may not apply to all men. Surgery carries standard risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 45 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Infertile married males diagnosed with clinical varicocele. * Age between 20-45 years. * Patients indicated for varicocelectomy according to standard clinical guidelines. * Abnormal or suboptimal semen parameters on at least two semen analyses. Exclusion Criteria: * Azoospermic patients (complete absence of sperm in semen). * History of previous varicocelectomy or scrotal surgery. * Presence of other known causes of infertility (e.g., genetic abnormalities, obstructive azoospermia). * Active genital infection or systemic infection affecting semen analysis. * Use of medications affecting spermatogenesis within the last 3 months (e.g., testosterone, chemotherapy). * Chronic systemic diseases known to affect fertility (e.g., uncontrolled diabetes, liver failure). * Severe leukocytospermia as confirmed by peroxidase (Endtz) test exceeding WHO reference limits. * Pus cell \> 1 million/ml by peroxidase.

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Conditions

The condition(s) this trial relates to.

infertility disorder male infertility varicocele

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertility Male infertility Varicocele Varicocelectomy

How to take part

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  1. The official record

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