Male infertility
MONDO:0005372The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.
Also known as: infertility disorder of male reproductive system, male reproductive system infertility, male reproductive system infertility disorder
92 clinical trials for this condition and its sub-types, 74 tagged with Male infertility itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Male infertility
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Azoospermia 25 trials
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Oligospermia 20 trials
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Spermatogenic failure 1 trial · 12 incl. sub-types
113 sub-types
- Spermatogenic failure 3 9 trials
- Spermatogenic failure, Y-linked, 2 5 trials
- Spermatogenic failure 34 1 trial
- Spermatogenic failure 6 1 trial
- X-linked spermatogenic failure 1 0 trials
- Spermatogenic failure 1 0 trials
- Spermatogenic failure 10 0 trials
- Spermatogenic failure 100 0 trials
- Spermatogenic failure 101 0 trials
- Spermatogenic failure 102 0 trials
- Spermatogenic failure 11 0 trials
- Spermatogenic failure 12 0 trials
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- Spermatogenic failure 15 0 trials
- Spermatogenic failure 16 0 trials
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- Spermatogenic failure 19 0 trials
- Spermatogenic failure 2 0 trials
- Spermatogenic failure 20 0 trials
- Spermatogenic failure 21 0 trials
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- Spermatogenic failure 24 0 trials
- Spermatogenic failure 25 0 trials
- Spermatogenic failure 26 0 trials
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- Spermatogenic failure 30 0 trials
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- Spermatogenic failure 40 0 trials
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- Spermatogenic failure 95 0 trials
- Spermatogenic failure 96 0 trials
- Spermatogenic failure 97 0 trials
- Spermatogenic failure 98 0 trials
- Spermatogenic failure 99 0 trials
- Spermatogenic failure, X-linked, 2 0 trials
- Spermatogenic failure, X-linked, 3 0 trials
- Spermatogenic failure, X-linked, 4 0 trials
- Spermatogenic failure, X-linked, 5 0 trials
- Spermatogenic failure, X-linked, 6 0 trials
- Spermatogenic failure, X-linked, 7 0 trials
- Spermatogenic failure, X-linked, 8 0 trials
- Spermatogenic failure, X-linked, 9 0 trials
- Spermatogenic failure, Y-linked, 1 0 trials
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Oligoasthenoteratozoospermia 11 trials
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Partial chromosome Y deletion 0 trials · 5 incl. sub-types
3 sub-types
- Spermatogenic failure, Y-linked, 2 5 trials
- Y chromosome infertility due to DAZ1 deletion 0 trials
- Spermatogenic failure, Y-linked, 1 0 trials
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Male infertility with teratozoospermia due to single gene mutation 0 trials · 1 incl. sub-types
3 sub-types
- Male infertility due to globozoospermia 0 trials · 1 incl. sub-types Sub-types →
- Spermatogenic failure 12 0 trials
- Spermatogenic failure 5 0 trials
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Could a simple supplement boost sperm health and IVF success?
Disease control CompletedThis trial tests whether a three-month course of the dietary supplement Stemregen can improve sperm quality in men with severe oligoasthenozoospermia, a condition marked by very low sperm count and poor movement. Researchers will compare semen parameters, sperm DNA damage, and ou…
Sponsor: Kocaeli University • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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Could a vitamin supplement boost male fertility and pregnancy odds?
Disease control CompletedThis trial tests whether Impryl, a nutritional supplement with B vitamins and zinc, can increase the chance of an ongoing pregnancy in couples where the male partner has subfertility. About 1,200 couples will take either Impryl or a placebo while starting fertility treatments lik…
Sponsor: Radboud University Medical Center • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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A hormone and a nutrient: a new combo to boost sperm count?
Disease control CompletedThis trial investigates whether adding DHEA to coenzyme Q10 improves sperm concentration in men with low sperm count (oligospermia). Half the participants will take DHEA plus CoQ10, while the other half takes CoQ10 alone, for three months. The study measures sperm concentration b…
Sponsor: Mst.Sumyara Khatun • Aim: Disease control
Last updated Aug 20, 2026 00:00 UTC
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Can fixing a varicocele beat antioxidants for boosting sperm?
Disease control CompletedThis trial tests whether microscopic surgery to repair varicoceles (enlarged veins in the scrotum) works better than antioxidant medication for men with cryptozoospermia—a condition where very few sperm are present in semen. About 69 men with clinical varicoceles will be randomly…
Sponsor: Sohag University • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Could a simple supplement revive sperm health and testosterone?
Disease control CompletedThis trial tests whether a daily supplement called WeNatal For Him can improve markers of male fertility, including sperm quality, testosterone levels, energy, and libido. Forty men aged 30 and older who report low energy and low libido will take three capsules each morning for t…
Sponsor: WeNatal • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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Can a common breast cancer drug and a supplement boost sperm quality?
Disease control CompletedThis study tested whether letrozole (a drug that lowers estrogen) and L-carnitine (a natural supplement) could improve sperm quality in 90 men with unexplained infertility. Participants took one of the treatments or a combination for three months. The goal was to see changes in s…
Phase 2/3 • Sponsor: Tehran University of Medical Sciences • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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Could a natural tablet help men with low sperm count?
Disease control CompletedThis study tested a natural product called FPT-20 in 16 men with sperm production problems due to testicular inflammation. Participants took one tablet daily for 6 to 12 months. The goal was to see if the supplement could increase sperm count and improve semen quality.
Sponsor: Trieu, Nguyen Thi, M.D. • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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Blood plasma boosts IVF success for men with Low-Quality sperm
Disease control CompletedThis study tested whether adding platelet-rich plasma (PRP) from a man's own blood to his sperm sample could improve embryo development during IVF. Researchers compared embryos from 66 men with severe sperm disorders, half treated with PRP and half without. The goal was to see if…
Phase 3 • Sponsor: Stella Maris Women and Children Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Could a steroid fix male infertility? new trial tests prednisone
Disease control CompletedThis study tested whether a short course of the steroid prednisone could improve sperm quality in men with infertility caused by inflammation. Researchers measured markers of oxidative stress and sperm health six months after treatment. The trial involved 200 men and compared pre…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Seaweed supplement could boost sperm quality in infertile men
Disease control CompletedThis study tested whether a daily supplement called TetraSOD®, made from a special marine microalgae, can improve sperm quality in men with unexplained infertility. Eighty men took either the supplement or a placebo for 90 days. The main goals were to see if sperm movement and co…
Sponsor: Fitoplancton Marino, S.L. • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New chip could pick healthier sperm for IVF
Disease control CompletedThis study tested a microfluidic chip that gently separates healthy, motile sperm from semen without harsh chemicals. Researchers compared it to the standard spinning method in 393 couples undergoing IVF for unexplained infertility. The goal was to see if the chip leads to higher…
Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Age matters: study hopes to boost fertility in klinefelter syndrome
Disease control CompletedThis study looked at 141 men with Klinefelter syndrome (47,XXY) to see if younger men (ages 15–22) have a better chance of finding sperm through testicular biopsy compared to older men (ages 23–55). Participants provided two semen samples, and if no sperm were found, they underwe…
Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Bone drug boosts sperm in infertile men?
Disease control CompletedThis study tested if denosumab, a drug usually used for bone loss, can improve sperm quality in men with very low sperm counts. 42 infertile men with a specific blood marker took part. The goal was to see if sperm concentration increased after 80 days of treatment.
Phase 1/2 • Sponsor: Martin Blomberg Jensen • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Ancient herbal tonic put to the test for male fertility
Disease control CompletedThis completed Phase 4 trial tested whether Guilu Erxian Oral Liquid, a traditional Chinese herbal remedy, can improve sperm count and movement in men with mild to moderate low sperm count or poor sperm motility. The study enrolled 360 married men aged 22 to 40 who also had a dia…
Phase 4 • Sponsor: DongE E Jiao Coporation Limited • Aim: Disease control
Last updated Jun 27, 2026 08:02 UTC
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PET scans may predict sperm retrieval success in infertile men
Diagnosis CompletedThis study looked at 160 men with azoospermia (no sperm in semen) to see if a special PET scan (FDG PET-CT) could tell which men would have sperm found during testicular extraction. The scan measures how active the testicles are. The goal was to compare scan results between men w…
Sponsor: University Hospital, Toulouse • Aim: Diagnosis
Last updated Jun 27, 2026 08:08 UTC
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Mindfulness may ease the emotional toll of infertility
Symptom relief CompletedThis study tested whether a simple mindfulness exercise—noticing natural changes in mood and body throughout the day—could improve wellbeing for couples dealing with infertility. 70 patients and their partners took part. The goal was to see if this low-cost, easy-to-learn approac…
Sponsor: Harvard University • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Walnuts may boost sperm quality, study finds
Symptom relief CompletedThis study tested whether eating two ounces of walnuts each day could improve sperm count, movement, and shape in men with fertility issues. 80 men took part, comparing walnuts to a standard multivitamin. The goal was to see if a simple diet change could help with natural or assi…
Sponsor: University of California, Los Angeles • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Do infertility treatments leave a metabolic mark on children?
Knowledge-focused CompletedResearchers at the University of California, San Francisco are running a long-term study to see whether children conceived through infertility treatment have different metabolic profiles than other children. The study has two parts: one looks back at children already born, and th…
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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At-Home sperm test could save couples time and worry
Knowledge-focused CompletedThis study looked at whether a simple home semen test can help couples find male fertility problems sooner. About 200 couples who were just starting to try for a baby used a home testing device. The goal was to see if it was easy to use and if it reduced stress while helping coup…
Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated Sep 05, 2026 00:00 UTC
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Gut protein zonulin: a hidden clue to male infertility?
Knowledge-focused CompletedThis study looks at whether levels of a protein called zonulin, found in blood and semen, differ between infertile men with and without varicocele (enlarged veins in the scrotum). Researchers will measure zonulin in 119 men and compare it with standard semen quality measures like…
Sponsor: Süleyman Tümer Çalışkan • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC
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Scientists dig into the mysteries of x and y chromosomes
Knowledge-focused CompletedThis study looked at 112 people with known differences in their sex chromosomes (X and Y) to better understand how these variations affect health, especially infertility. Participants underwent physical exams, blood and urine tests, imaging, and sensory checks over about 5 days. …
Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Sperm vacuoles may reveal hidden DNA damage
Knowledge-focused CompletedThis study looked at 200 men with sperm abnormalities to see if vacuoles (tiny holes) in the sperm head are linked to DNA damage. Researchers used high-powered microscopes and genetic tests to measure vacuole size and chromosome errors. The goal is to help doctors pick healthier …
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Smaller cut, same hope: study seeks to predict sperm retrieval success
Knowledge-focused CompletedThis study looked at 248 men with very low or no sperm in their semen to see if a less-invasive, mini-incision surgery could successfully retrieve sperm. Researchers checked whether factors like hormone levels or medical history could predict who would benefit from this smaller p…
Sponsor: Clinique Ovo • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Healthy men test two versions of fertility drug in bioequivalence study
Knowledge-focused CompletedThis study tested whether a new liquid form of follitropin alfa (a hormone used for fertility) works the same as the standard powder form. Fifty-five healthy men with low testosterone levels were given both versions at different times. The goal was to compare how the drug is abso…
Phase 1 • Sponsor: EMD Serono Research & Development Institute, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Simple blood test may predict fertility treatment success
Knowledge-focused CompletedThis study looked at whether a blood test measuring certain hormones (Inhibin B and FSH) can predict the type of testicular damage in men with a condition called non-obstructive azoospermia, where no sperm are found in the semen. Researchers analyzed data from 73 men who had a su…
Sponsor: Elazıg Fethi Sekin Sehir Hastanesi • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Timing of sperm extraction may influence IVF live birth rates
Knowledge-focused CompletedThis study looked at 129 men with low or no sperm in their semen who had sperm surgically removed from the testicle (micro-TESE) for IVF. Researchers compared doing the sperm retrieval 24 hours versus 48 hours before the egg retrieval to see if timing affected live birth rates. T…
Sponsor: Clinique Ovo • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC
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Could belly fat be hurting your sperm? new study investigates
Knowledge-focused CompletedThis study examined 170 men from couples struggling with infertility to see if metabolic syndrome—a cluster of conditions like high blood pressure, high blood sugar, and abnormal cholesterol—is linked to poor sperm quality. Researchers measured sperm count and other sperm feature…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Chemo's genetic impact on sperm revealed in new study
Knowledge-focused CompletedThis study looks at how chemotherapy changes sperm DNA in men with cancer. Researchers collect semen samples before treatment and one week after the first round of chemo. They compare the DNA and quality of the sperm to understand short-term effects. The goal is to learn more abo…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:53 UTC