Male infertility

This study tested whether letrozole (a drug that lowers estrogen) and L-carnitine (a natural supplement) could improve sperm quality in 90 men with unexplained infertility. Participants took one of the treatments or a combination for three months. The goal was to see changes in s…

This study tested a natural product called FPT-20 in 16 men with sperm production problems due to testicular inflammation. Participants took one tablet daily for 6 to 12 months. The goal was to see if the supplement could increase sperm count and improve semen quality.

This study tested whether adding platelet-rich plasma (PRP) from a man's own blood to his sperm sample could improve embryo development during IVF. Researchers compared embryos from 66 men with severe sperm disorders, half treated with PRP and half without. The goal was to see if…

This study looked at 99 IVF patients with endometriosis (a condition where uterine-like tissue grows elsewhere) and a positive BCL6 test. It compared a cheap oral pill (norethindrone acetate) to an expensive injection (Depo Lupron) given before embryo transfer. The goal was to se…

This study tested whether a short course of the steroid prednisone could improve sperm quality in men with infertility caused by inflammation. Researchers measured markers of oxidative stress and sperm health six months after treatment. The trial involved 200 men and compared pre…

This study tested whether a daily supplement called TetraSOD®, made from a special marine microalgae, can improve sperm quality in men with unexplained infertility. Eighty men took either the supplement or a placebo for 90 days. The main goals were to see if sperm movement and co…

This study tested a ready-to-use calcium ionophore medium (GM508 CultActive) on eggs from 68 IVF patients who had low fertilization rates, poor embryo quality, or were over 40. The medium was applied shortly after sperm injection to try to improve fertilization and embryo develop…

This study tested whether giving a small daily dose of a hormone (human menopausal gonadotropin) after egg retrieval could improve the chance of a live birth in women undergoing IVF. 600 women aged 20-40 took part. The researchers compared live birth rates between those who got t…

This completed trial tested a new device called HyperSperm that prepares sperm for IVF or ICSI. Researchers compared it to standard sperm preparation in 41 couples. The goal was to see if the new method leads to more embryos reaching the blastocyst stage, which is key for success…

This study tested a microfluidic chip that gently separates healthy, motile sperm from semen without harsh chemicals. Researchers compared it to the standard spinning method in 393 couples undergoing IVF for unexplained infertility. The goal was to see if the chip leads to higher…

This study looked at 141 men with Klinefelter syndrome (47,XXY) to see if younger men (ages 15–22) have a better chance of finding sperm through testicular biopsy compared to older men (ages 23–55). Participants provided two semen samples, and if no sperm were found, they underwe…

This study tested if denosumab, a drug usually used for bone loss, can improve sperm quality in men with very low sperm counts. 42 infertile men with a specific blood marker took part. The goal was to see if sperm concentration increased after 80 days of treatment.

This study tested a high dose of a fertility drug called follitropin delta, mixed with another hormone (hCG), in 118 women undergoing IVF. The goal was to see if this combination could improve the number of good-quality embryos. The study was completed and focused on women aged 1…

This completed Phase 4 trial tested whether Guilu Erxian Oral Liquid, a traditional Chinese herbal remedy, can improve sperm count and movement in men with mild to moderate low sperm count or poor sperm motility. The study enrolled 360 married men aged 22 to 40 who also had a dia…

This study tested two new technologies—optical genome mapping and long-read DNA sequencing—against standard chromosome tests in 350 people with infertility, intellectual disability, birth defects, or miscarriage. The goal was to see if these newer methods can find more chromosome…

This study looked at 160 men with azoospermia (no sperm in semen) to see if a special PET scan (FDG PET-CT) could tell which men would have sperm found during testicular extraction. The scan measures how active the testicles are. The goal was to compare scan results between men w…

This study tested whether a simple mindfulness exercise—noticing natural changes in mood and body throughout the day—could improve wellbeing for couples dealing with infertility. 70 patients and their partners took part. The goal was to see if this low-cost, easy-to-learn approac…

This study tested whether eating two ounces of walnuts each day could improve sperm count, movement, and shape in men with fertility issues. 80 men took part, comparing walnuts to a standard multivitamin. The goal was to see if a simple diet change could help with natural or assi…

This study tested whether taking melatonin, a natural antioxidant, can improve egg quality and pregnancy rates in women undergoing IVF. Eighty infertile women received either melatonin or a placebo. Researchers measured melatonin levels in ovarian fluid and tracked egg maturation…

This study tested a device called the Alife Hera System, which uses a computer algorithm to score embryos based on images and patient information. The goal was to see if using this score alongside standard methods helps doctors choose the embryo most likely to result in a pregnan…

This study reviewed 1251 intrauterine insemination (IUI) cycles at one hospital to see if the type of fertility drug used or the cause of infertility affected pregnancy rates. Participants were women aged 20-44 with normal ovulation and their partners with adequate sperm. The res…

This study looked at 112 people with known differences in their sex chromosomes (X and Y) to better understand how these variations affect health, especially infertility. Participants underwent physical exams, blood and urine tests, imaging, and sensory checks over about 5 days. …

This study looked at 200 men with sperm abnormalities to see if vacuoles (tiny holes) in the sperm head are linked to DNA damage. Researchers used high-powered microscopes and genetic tests to measure vacuole size and chromosome errors. The goal is to help doctors pick healthier …

This study looked at 110 women aged 35-40 with low ovarian reserve undergoing IVF. Half received a mild stimulation (clomiphene plus low-dose hormones) and half received a stronger stimulation (higher-dose hormones). The goal was to see which approach led to more good-quality bla…

This study looked at whether using frozen embryos instead of fresh ones in IVF leads to more live births. 237 women took part, and researchers compared pregnancy rates and baby health. The goal was to see if freezing embryos helps the womb lining work better.

This study looked at whether a simple home semen test can help couples find male fertility problems sooner. About 200 couples who were just starting to try for a baby used a home testing device. The goal was to see if it was easy to use and if it reduced stress while helping coup…

This study looked at whether the level of thyroid-stimulating hormone (TSH) in the blood affects the success of a fertility treatment called ICSI. Researchers measured TSH in 180 women on day 2-3 of their menstrual cycle and then tracked egg retrieval, fertilization, and pregnanc…

This study looked at over 5,800 couples who had a first baby through fertility treatment at an Italian clinic. Researchers wanted to see how many came back for more treatment to have a second or third child, and what factors—like age or frozen embryos—affected that decision. The …

This study looked at 248 men with very low or no sperm in their semen to see if a less-invasive, mini-incision surgery could successfully retrieve sperm. Researchers checked whether factors like hormone levels or medical history could predict who would benefit from this smaller p…

This study tested whether a new liquid form of follitropin alfa (a hormone used for fertility) works the same as the standard powder form. Fifty-five healthy men with low testosterone levels were given both versions at different times. The goal was to compare how the drug is abso…

This study looked at whether a blood test measuring certain hormones (Inhibin B and FSH) can predict the type of testicular damage in men with a condition called non-obstructive azoospermia, where no sperm are found in the semen. Researchers analyzed data from 73 men who had a su…

This study compared two advanced embryo culture systems used in IVF with ICSI. One system has a built-in camera to watch embryos continuously, while the other uses periodic microscope checks. Researchers wanted to see if either system leads to more embryos implanting successfully…

This study tested an artificial intelligence tool called EMA to see if it can rank embryos better than traditional methods for IVF. Researchers looked at data from 333 people who had IVF between 2022 and 2023. The goal was to see if the AI's scores matched up with expert embryolo…

This study looked at over 1,200 women under 40 who had a frozen embryo transfer. Some used a natural cycle with no hormones, while others took estrogen and progesterone to mimic a natural cycle. The goal was to see which method leads to more pregnancies. Results could help clinic…

This study looked at 158 women having intrauterine insemination (IUI) to see if progesterone levels on the day of insemination are linked to pregnancy rates. IUI is a simpler, cheaper fertility treatment than IVF, but success rates are low. Researchers measured progesterone and o…

This study looked at 129 men with low or no sperm in their semen who had sperm surgically removed from the testicle (micro-TESE) for IVF. Researchers compared doing the sperm retrieval 24 hours versus 48 hours before the egg retrieval to see if timing affected live birth rates. T…

This study tested a robotic assistant to automate key steps in the IVF lab, such as preparing sperm and eggs, injecting sperm into eggs (ICSI), and freezing embryos. Researchers compared the robot's performance to standard manual methods using eggs and embryos from 42 couples und…

This study examined 170 men from couples struggling with infertility to see if metabolic syndrome—a cluster of conditions like high blood pressure, high blood sugar, and abnormal cholesterol—is linked to poor sperm quality. Researchers measured sperm count and other sperm feature…

This study observed 201 women in Nordic countries and Switzerland who were using the fertility drug REKOVELLE® for the first time during IVF or ICSI. Researchers tracked how doctors prescribed the drug, including dose adjustments and use of a dosing app, to understand real-world …

This study looks at how chemotherapy changes sperm DNA in men with cancer. Researchers collect semen samples before treatment and one week after the first round of chemo. They compare the DNA and quality of the sperm to understand short-term effects. The goal is to learn more abo…

This study looked at 87 women who had no eggs retrieved during their first IVF cycle. Researchers wanted to see if a second round of ovulation-inducing medication could lead to successful egg retrieval. The goal was to understand which factors might predict failure and how to imp…

This study looked at genes in cumulus cells (cells that surround eggs) from 137 women undergoing IVF. The goal was to find genetic markers that predict which embryos are most likely to lead to a pregnancy. Researchers compared two different hormone treatments to see if gene patte…