Can a common breast cancer drug and a supplement boost sperm quality?

NCT ID NCT07669402

Completed Disease control Sponsor: Tehran University of Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This study tested whether letrozole (a drug that lowers estrogen) and L-carnitine (a natural supplement) could improve sperm quality in 90 men with unexplained infertility. Participants took one of the treatments or a combination for three months. The goal was to see changes in sperm count, movement, and shape, as well as markers of oxidative stress. Results could lead to new, non-invasive fertility treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Letrozole and L-carnitine
What this could lead to: If successful, this could point toward a simple, drug-based way to improve sperm quality and fertility outcomes in men with unexplained infertility.
What could go wrong: This is a small, early-phase trial (90 men) with short treatment duration. Results may not apply to all men, and benefits may be modest or not lead to higher pregnancy rates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for IDIOPATHIC OLIGOASTHENOTERATOZOOSPERMIA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

male infertility oligoasthenoteratozoospermia oligospermia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC OLIGOASTHENOTERATOZOOSPERMIA MALE INFERTILITY

Contacts and locations

Locations

Shariati Hospital, Tehran University of Medical Sciences

Tehran, 1417613151, Iran

More trials for these conditions

Other studies related to the condition(s) this trial covers.