Can a common breast cancer drug and a supplement boost sperm quality?
NCT ID NCT07669402
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This study tested whether letrozole (a drug that lowers estrogen) and L-carnitine (a natural supplement) could improve sperm quality in 90 men with unexplained infertility. Participants took one of the treatments or a combination for three months. The goal was to see changes in sperm count, movement, and shape, as well as markers of oxidative stress. Results could lead to new, non-invasive fertility treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Letrozole and L-carnitine
What this could lead to
If successful, this could point toward a simple, drug-based way to improve sperm quality and fertility outcomes in men with unexplained infertility.
What could go wrong
This is a small, early-phase trial (90 men) with short treatment duration. Results may not apply to all men, and benefits may be modest or not lead to higher pregnancy rates.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Shariati Hospital, Tehran University of Medical Sciences
Tehran, 1417613151, Iran