Could a sleep hormone boost IVF success?

NCT ID NCT07343947

Completed Symptom relief Sponsor: University of Sao Paulo General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking melatonin, a natural antioxidant, can improve egg quality and pregnancy rates in women undergoing IVF. Eighty infertile women received either melatonin or a placebo. Researchers measured melatonin levels in ovarian fluid and tracked egg maturation, embryo development, and pregnancy. The goal is to see if this simple supplement can help women struggling with infertility.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: melatonin
What this could lead to: If it works, this could point toward a simple, low-cost supplement to improve IVF success rates.
What could go wrong: This is a small, completed trial with 80 participants. Melatonin is not a standard fertility treatment, and results may not apply to all women or lead to higher pregnancy rates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFERTILE WOMEN UNDERGOING IVF OR ICSI INFERTILITY INFERTILITY (IVF PATIENTS)

Contacts and locations

Locations

Univertity of Sao Paulo, Clinics Hospital

São Paulo, São Paulo, Brazil

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