Can a sperm 'Quality Check' boost IVF success?
NCT ID NCT05017740
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial tests whether a technique called PICSI, which selects sperm by their ability to bind to hyaluronic acid, can improve pregnancy rates and reduce miscarriage compared to standard ICSI. It involves couples who had poor fertilization in their first IVF cycle and are now trying again. The goal is to see if this sperm selection method makes a meaningful difference in achieving a healthy pregnancy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PICSI (physiological intracytoplasmic sperm injection) - a procedure where sperm are selected by binding to hyaluronic acid before being injected into an egg during IVF.
- What this could lead to
- If PICSI proves better than standard ICSI, it could offer a simple way to improve pregnancy chances and lower miscarriage risk for couples who have struggled with poor fertilization in IVF.
- What could go wrong
- This is a small, early-stage trial, and previous evidence on PICSI is mixed. It may not show a clear benefit, and the procedure adds an extra step to IVF without guaranteed improvement.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
KK Women's and Children's Hospital
Singapore, 229899, Singapore
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