A pill instead of a needle? new IVF trial tests drospirenone for women with low ovarian reserve

NCT ID NCT07736261

Not yet recruiting Disease control Sponsor: Ahmed Saad Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This pilot trial tests whether a daily drospirenone pill can replace standard daily injections during ovarian stimulation for women with poor ovarian reserve undergoing IVF. Participants take either drospirenone or the usual injection alongside their fertility hormones, then have all embryos frozen for later transfer. The study compares the number of mature eggs retrieved and tracks treatment experience through questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: a daily pill called drospirenone, compared with a standard daily injection called cetrorelix
What this could lead to: If drospirenone works as well as the standard injection, it could offer a simpler, needle-free option for ovarian stimulation in women with low egg reserve.
What could go wrong: This is a small pilot trial, so results may not be definitive. Drospirenone may not prevent premature ovulation as effectively as the standard injection, and its effects on pregnancy rates are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFERTILITY (IVF PATIENTS) POOR OVARIAN RESERVE

Contacts and locations

Locations

Hawaa Fertility Center

Banhā, Qalyubia Governorate, 13512, Egypt

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