IVF debate: does less stimulation mean better embryos?
NCT ID NCT04983173
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looked at 110 women aged 35-40 with low ovarian reserve undergoing IVF. Half received a mild stimulation (clomiphene plus low-dose hormones) and half received a stronger stimulation (higher-dose hormones). The goal was to see which approach led to more good-quality blastocysts. Researchers also tracked hormone changes and egg counts to understand how stimulation intensity affects early embryo development.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Clomiphene citrate and recombinant follicle-stimulating hormone (rFSH)
- What this could lead to
- If successful, this could help doctors choose the best stimulation intensity for IVF patients with low ovarian reserve, potentially improving embryo quality.
- What could go wrong
- This is a small, completed Phase 4 trial with only 110 participants. Results may not apply to all infertility patients, and the study focuses on embryo quality, not live birth rates.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for INFERTILITY are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Salud de la Mujer Dexeus
Barcelona, 08028, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can 'Abnormal' embryos still lead to healthy pregnancies? a new registry investigates
- Building a biological treasure trove to decode Women's health mysteries
- Can a sperm 'Quality Check' boost IVF success?
- Foam ultrasound for fertility checks: will women find it comfortable?
- A Hormone's hidden power: could progesterone be the key to unexplained infertility?
- A questionnaire to empower fertility patients — a pilot study puts it to the test