Could a steroid fix male infertility? new trial tests prednisone

NCT ID NCT01407484

Completed Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a short course of the steroid prednisone could improve sperm quality in men with infertility caused by inflammation. Researchers measured markers of oxidative stress and sperm health six months after treatment. The trial involved 200 men and compared prednisone to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Prednisone (a corticosteroid anti-inflammatory drug)
What this could lead to: If it works, this could point toward a treatment for male infertility caused by inflammation, potentially improving sperm quality and fertility.
What could go wrong: This is a small, early-stage trial with only 200 participants. The treatment is short-term and may not lead to lasting improvement. Risks include side effects from steroids like weight gain or mood changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infertility disorder leukopenia male infertility post-infectious disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEUKOPENIA MALE INFERTILITY OXIDATIVE STRESS POSTINFECTION INFLAMMATION

Contacts and locations

Locations

Cochin Hospital

Paris, 75014, France

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