Age matters: study hopes to boost fertility in klinefelter syndrome

NCT ID NCT01918280

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 141 men with Klinefelter syndrome (47,XXY) to see if younger men (ages 15–22) have a better chance of finding sperm through testicular biopsy compared to older men (ages 23–55). Participants provided two semen samples, and if no sperm were found, they underwent a biopsy. The goal is to improve fertility preservation by identifying the best age for sperm retrieval.

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Conditions

The condition(s) this trial relates to.

azoospermia Klinefelter syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Groupe de Médecine de la Reproduction - CECOS Midi-Pyrénées - Hôpital Paule de Viguier)

    Toulouse, 31059, France

  • Service d'Endocrinologie Moléculaire et Maladies Rares, Centre de Biologie Est, Hospices Civils de Lyon

    Bron, 69677, France

  • Service de Biologie de la Reproduction - CECOS - Groupe Hospitalier Pellegrin

    Bordeaux, 33076, France

  • Service de Biologie de la Reproduction - Hôpital de la Conception

    Marseille, 13385, France