Can hormone balancing boost fertility and health in klinefelter syndrome?

NCT ID NCT05586802

Recruiting now Disease control Sponsor: Georgios Papadakis Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adjusting sex hormone levels with aromatase inhibitors can improve metabolic health and sperm production in men with Klinefelter syndrome. It also examines if adding semaglutide (a weight-loss drug) or hCG provides extra benefits. The trial involves 150 men and compares these approaches to standard testosterone therapy.

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Conditions

The condition(s) this trial relates to.

infertility disorder Klinefelter syndrome metabolic syndrome X

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KLINEFELTER SYNDROME

Contacts and locations

Locations

Service of Endocrinology, Diabetes & Metabolism
RECRUITING

Lausanne, 1011, Switzerland

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