Male infertility

This study tests a new way to prepare sperm for in vitro fertilization (IVF) called HyperSperm. It compares the safety and effectiveness of this method to standard sperm preparation. The trial will involve 202 couples undergoing IVF and will measure how many embryos are healthy (…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase pregnancy rates. About 288 women with infertility will be randomly assigned to receive either standard IUI or IUI with PRP-treated…

This study tests a new device that sorts sperm without spinning them, which may reduce DNA damage often seen in older men. It involves 378 couples where the male partner is 40 or older and the female partner has at least 5 mature eggs. The goal is to see if this device leads to m…

This study tests a more thorough varicocele surgery that strips away extra veins, compared to the standard method. About 160 infertile men with varicocele will be randomly assigned to one of the two procedures. The goal is to see if the extended stripping reduces the chance of va…

This study tests whether a modified dual trigger (a mix of HCG and two doses of a GnRH agonist) works better than the standard HCG trigger for ovulation in women undergoing IVF. About 196 women with normal egg reserves will participate. The goal is to see if the new method improv…

This early study tests a drug called leflutrozole in 15 men who have no sperm in their semen due to a blockage-free cause. The drug is taken as a weekly capsule and aims to boost sperm production. Researchers will check if sperm appear in the semen after 12-20 weeks of treatment.

This study tests whether giving two medications (a GnRH agonist and HCG) instead of just HCG can help women with low ovarian response produce more mature eggs for IVF. About 164 women will be randomly assigned to receive either the double trigger or the standard HCG trigger. The …

This study tests whether giving men with low testosterone and no sperm in their ejaculate a combination of two hormones (hCG and FSH) can help them produce usable sperm for IVF. About 860 men will either receive the hormone therapy or standard care for 16 weeks. The goal is to se…

This study compares a new method that combines a non-invasive genetic test (NICS) with artificial intelligence (AI) against the standard way of picking embryos by looks alone. It includes 520 women aged 35-43 or with a history of recurrent miscarriage who are doing IVF. The goal …

This study tests an AI-driven device called BAIBYS™ that automatically selects sperm based on movement, size, and shape for use in IVF. Half of the eggs from each couple will be fertilized using sperm chosen by the AI, and the other half using the standard manual method. The goal…

This study tests whether taking royal jelly, a bee product, can improve sperm DNA quality and pregnancy rates in couples with unexplained infertility. Eighty men will take either royal jelly or a placebo daily for three months. Researchers will measure sperm damage, hormone level…

This study tests whether mixing a woman's own platelet-rich plasma (PRP) with her partner's sperm before intrauterine insemination (IUI) can increase the chance of pregnancy. About 288 women with infertility will be randomly assigned to receive either PRP-treated sperm or standar…

This study will compare two advanced sperm selection techniques—PICSI and the ZyMot device—used during ICSI (a type of IVF). The goal is to see which method leads to more pregnancies. 300 couples will take part, with women aged 20-39. The results could help fertility clinics choo…

This study tests whether two popular weight-loss drugs, semaglutide and tirzepatide, can improve sperm quality and help obese men have children naturally. About 180 men will receive either lifestyle advice, semaglutide, or tirzepatide for 32 weeks. Researchers will measure change…

This study aims to develop and validate an artificial intelligence tool that analyzes sperm quality using microfluidic technology. Researchers will test the tool on 200 men undergoing IVF or artificial insemination. The goal is to provide a more accurate, standardized diagnosis a…

This study tests an artificial intelligence algorithm called SiDTM v2.0 that helps embryologists choose the best sperm for a procedure called ICSI (a type of IVF). Currently, sperm selection is done by eye, which can vary between experts. The AI scores each sperm based on shape a…

This study looks at a fertility drug called corifollitropin alfa in women aged 36 to 40 who are doing IVF. The goal is to see if the drug is safe and helps produce eggs. Researchers will track side effects and pregnancy rates over one year.

This study tests whether taking progesterone (a hormone) after intrauterine insemination (IUI) increases the chance of pregnancy in women who also took letrozole to stimulate their ovaries. About 690 women in Denmark will be randomly assigned to receive either progesterone vagina…

This study tests whether adding pure platelet-rich plasma (P-PRP) to sperm samples can improve sperm movement (motility) in a lab. Researchers will first standardize how to make P-PRP, then compare sperm quality after 24 hours with and without P-PRP. The trial involves 248 partic…

This study will look back at records from 92 IVF patients whose embryos came from abnormally fertilized eggs. Researchers want to see how often these embryos lead to pregnancy and live birth. The goal is to help fertility doctors make better decisions about whether to use such em…

This study will follow about 484 couples undergoing a type of IVF called ICSI to see if sperm DNA damage affects their chances of having a baby. Researchers will measure DNA breaks in sperm before and after a washing step, then track pregnancy and live birth rates. The goal is to…

This large observational study will follow 4,000 young cancer survivors (ages 15-39) across Europe to understand how different cancer treatments impact fertility, hormone function, and pregnancy outcomes. Researchers will also evaluate the safety and success of fertility preserva…

This study tests two different calcium treatments (ionophores) to help eggs fertilize during IVF when previous attempts failed. Researchers will compare which treatment works better and check embryo health. The study involves 20 couples with a history of low fertilization.

This study will measure microplastics in semen, follicular fluid, and other samples from 1000 men and women seeking fertility treatment. Researchers will check if higher microplastic levels are linked to lower pregnancy rates and poorer egg or sperm quality. The goal is to better…

This study looks at 40 infertile men with varicoceles (enlarged veins in the scrotum) to see if blood flow measurements in the testicles can predict how well they will respond to surgery. Participants will have ultrasound and blood tests before and three months after a standard m…

This observational study looks at embryos from IVF that are not used for pregnancy to find molecular patterns related to embryo quality. Researchers hope to learn why some embryos are healthy and others are not, which could improve future fertility treatments. About 150 patients …

This study looks at a new program that helps children aged 6 to 18 with mild mental health issues get faster care by improving how doctors, nurses, and community providers work together. Researchers will interview healthcare professionals and families to find out what helps or hi…

This study will look at over 1,000 men visiting fertility clinics across India to understand how common male infertility is and what factors like smoking, obesity, and location might play a role. Researchers will use a new system called the Aphrodite Criteria to get a clearer pic…

This study tests whether rinsing (flushing) ovarian follicles during egg retrieval can increase the number of mature eggs collected for IVF. In 75 women undergoing IVF, one ovary will be flushed and the other will not, and the egg yields will be compared. The goal is to see if th…

This pilot study will follow 90 men aged 18-50 who need heart surgery, some of whom will take the blood thinner warfarin afterward. Researchers will track changes in sperm count, movement, shape, DNA health, and hormone levels over 12 months. The goal is to see if warfarin harms …

This study will look at 80 men with non-obstructive azoospermia (no sperm in semen due to poor sperm production) who are scheduled for bilateral microscopic testicular sperm extraction (micro-TESE). The goal is to see how often sperm can be successfully retrieved from a single te…