Heart drug warfarin under scrutiny for male fertility risks

NCT ID NCT07330869

Not yet recruiting Knowledge-focused Sponsor: Città di Lecce Hospital, GVM Care & Research Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study will follow 90 men aged 18-50 who need heart surgery, some of whom will take the blood thinner warfarin afterward. Researchers will track changes in sperm count, movement, shape, DNA health, and hormone levels over 12 months. The goal is to see if warfarin harms male fertility, which could help doctors better counsel patients about family planning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: warfarin
What this could lead to: If this study finds a link, it could lead to better counseling and fertility preservation for young men needing warfarin after heart surgery.
What could go wrong: This is a small pilot study, not a treatment trial. It only observes possible effects and cannot prove cause. Results may not apply to all men.

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Conditions

The condition(s) this trial relates to.

heart valve disorder Inflammation male infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART VALVE DISEASE MALE INFERTILITY

Contacts and locations

Locations

Città di Lecce Hospital - Department of Cardiac Surgery

Lecce, LE, 73100, Italy

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