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New surgical twist may boost fertility after varicocele repair

NCT ID NCT07605351

Disease control Sponsor: Benha University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a more thorough varicocele surgery that strips away extra veins, compared to the standard method. About 160 infertile men with varicocele will be randomly assigned to one of the two procedures. The goal is to see if the extended stripping reduces the chance of varicocele coming back and improves sperm quality over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
surgical procedure
What this could lead to
If the new technique works, it could lower the chance of varicocele coming back after surgery and improve fertility outcomes.
What could go wrong
This is a small, early-stage trial with only 160 men, so results may not apply to everyone. Surgery always carries risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male patients aged 18 to 50 years. * Couple infertility for at least 12 months. * Clinically palpable grade I to III varicocele confirmed by physical examination. * Abnormal semen parameters documented on at least two semen analyses performed 2 to 4 weeks apart according to World Health Organization laboratory standards. * Female partner evaluation completed or planned, with no untreated severe female factor that would make natural conception impossible. * Willingness to comply with postoperative follow-up at 3, 6, and 12 months. * Written informed consent. Exclusion Criteria: * Azoospermia or cryptozoospermia, defined as absence of sperm in the native ejaculate on at least two baseline semen analyses, including cases in which sperm are detected only after centrifugation. * Known clinically significant chromosomal or genetic abnormality that independently explains severe male infertility, when identified before enrollment. * Previous varicocelectomy of the index side. * Previous inguinal, scrotal, or retroperitoneal surgery that may alter spermatic cord anatomy. * Subclinical varicocele only. * Isolated scrotal pain with normal semen parameters. * Hypogonadotropic hypogonadism requiring hormonal induction therapy. * Testosterone therapy within the previous 6 months. * Use of anti-estrogens, gonadotropins, or aromatase inhibitors within the previous 3 months. * Active genitourinary infection. * Testicular tumor or history of testicular cancer. * Severe systemic disease contraindicating surgery or anesthesia. * Inability to provide informed consent. * Inability or unwillingness to complete follow-up.

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Conditions

The condition(s) this trial relates to.

male infertility varicocele

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Male infertility Varicocele

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Benha University Hospital

    Banhā, Qalyubia Governorate, 13511, Egypt

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