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Male infertility
MONDO:0005372The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.
Also known as: infertility disorder of male reproductive system, male reproductive system infertility, male reproductive system infertility disorder
92 clinical trials for this condition and its sub-types, 74 tagged with Male infertility itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Male infertility
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Azoospermia 25 trials
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Oligospermia 20 trials
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Spermatogenic failure 1 trial · 12 incl. sub-types
113 sub-types
- Spermatogenic failure 3 9 trials
- Spermatogenic failure, Y-linked, 2 5 trials
- Spermatogenic failure 34 1 trial
- Spermatogenic failure 6 1 trial
- X-linked spermatogenic failure 1 0 trials
- Spermatogenic failure 1 0 trials
- Spermatogenic failure 10 0 trials
- Spermatogenic failure 100 0 trials
- Spermatogenic failure 101 0 trials
- Spermatogenic failure 102 0 trials
- Spermatogenic failure 11 0 trials
- Spermatogenic failure 12 0 trials
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- Spermatogenic failure 15 0 trials
- Spermatogenic failure 16 0 trials
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- Spermatogenic failure 19 0 trials
- Spermatogenic failure 2 0 trials
- Spermatogenic failure 20 0 trials
- Spermatogenic failure 21 0 trials
- Spermatogenic failure 22 0 trials
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- Spermatogenic failure 26 0 trials
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- Spermatogenic failure 30 0 trials
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- Spermatogenic failure 35 0 trials
- Spermatogenic failure 36 0 trials
- Spermatogenic failure 37 0 trials
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- Spermatogenic failure 4 0 trials
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- Spermatogenic failure 9 0 trials
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- Spermatogenic failure 95 0 trials
- Spermatogenic failure 96 0 trials
- Spermatogenic failure 97 0 trials
- Spermatogenic failure 98 0 trials
- Spermatogenic failure 99 0 trials
- Spermatogenic failure, X-linked, 2 0 trials
- Spermatogenic failure, X-linked, 3 0 trials
- Spermatogenic failure, X-linked, 4 0 trials
- Spermatogenic failure, X-linked, 5 0 trials
- Spermatogenic failure, X-linked, 6 0 trials
- Spermatogenic failure, X-linked, 7 0 trials
- Spermatogenic failure, X-linked, 8 0 trials
- Spermatogenic failure, X-linked, 9 0 trials
- Spermatogenic failure, Y-linked, 1 0 trials
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Oligoasthenoteratozoospermia 11 trials
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Partial chromosome Y deletion 0 trials · 5 incl. sub-types
3 sub-types
- Spermatogenic failure, Y-linked, 2 5 trials
- Y chromosome infertility due to DAZ1 deletion 0 trials
- Spermatogenic failure, Y-linked, 1 0 trials
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Male infertility with teratozoospermia due to single gene mutation 0 trials · 1 incl. sub-types
3 sub-types
- Male infertility due to globozoospermia 0 trials · 1 incl. sub-types Sub-types →
- Spermatogenic failure 12 0 trials
- Spermatogenic failure 5 0 trials
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Fertility drug trial for men with no sperm pulled before it began
Disease control CancelledThis study aimed to see if the drug clomiphene citrate could help men with a condition called non-obstructive azoospermia, where the body produces little to no sperm. The plan was to give the drug or a placebo for nine months, then check if sperm could be found in the semen or th…
Phase 3 • Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Can acne drug or hormone shots help men with low sperm count?
Disease control By invitation onlyThis study tests two treatments—isotretinoin (an acne medication) and hCG (a hormone)—to see if they can help men with low or no sperm count produce moving sperm. About 100 men aged 19 to 50 will take one of the drugs for three months. The goal is to find new options for male inf…
Phase 2 • Sponsor: University of Nebraska • Aim: Disease control
Last updated Jun 27, 2026 12:10 UTC
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Could two existing drugs unlock sperm production in infertile men?
Disease control OngoingThis early study tests whether two drugs—denosumab and letrozole—can help men with a specific type of infertility (non-obstructive azoospermia) start producing sperm. Sixteen men will take the drugs for about three months, and researchers will check for sperm in their semen or te…
Phase 1/2 • Sponsor: Martin Blomberg Jensen • Aim: Disease control
Last updated Jun 27, 2026 12:09 UTC
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Fertility drug showdown: which boosts sperm better?
Disease control By invitation onlyThis study compares two medications—gonadotropin and clomiphene citrate—to see which better improves sperm health in men with fertility problems. About 500 men with abnormal sperm analysis will be randomly assigned to one of the drugs. The goal is to measure changes in sperm coun…
Phase 4 • Sponsor: Szeged University • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Gene mutation may unlock L-Carnitine's power for sperm health
Disease control OngoingThis study looks at whether men with a specific gene mutation (TDRD9) get more benefit from L-carnitine, a common supplement, to improve sperm count and movement. About 50 men with low sperm count and motility will take L-carnitine for 3 months. Researchers will compare changes i…
Phase 3 • Sponsor: South Valley University • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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New sperm-sorting chip could boost IVF success rates
Disease control OngoingThis study compares a new microfluidic device, SwimCount Harvester, to standard sperm preparation methods in couples undergoing IVF with genetic testing (PGT-A). About 1,600 couples will be randomly assigned to one of the two methods. The goal is to see if the device leads to mor…
Sponsor: MotilityCount aps • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Frozen testicle tissue may help infertile men have kids
Disease control OngoingThis experimental study tests whether frozen-thawed testis tissue, when grafted under the skin, can produce sperm in men with infertility. Five men will receive their own stored tissue. The goal is to see if viable sperm can be retrieved, potentially offering a future fertility o…
Sponsor: Herlev and Gentofte Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Needle instead of scalpel: new sperm retrieval method tested
Disease control OngoingThis study tests a non-surgical method to collect sperm from men with a condition called azoospermia, where no sperm is found in the semen. Using ultrasound guidance, doctors flush and suction fluid from a part of the testicle to retrieve sperm. If successful, this could help inf…
Sponsor: University of Pittsburgh • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New sperm test could predict IVF success
Diagnosis OngoingThis study is testing a new sperm quality test called SpermQT. It aims to see if the test can predict how likely a couple is to get pregnant with treatments like IUI or IVF. About 1,000 couples will take part, and researchers will track pregnancy outcomes based on the test result…
Sponsor: Inherent Biosciences • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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Can cannabis alter sperm and testosterone? a trial seeks answers
Knowledge-focused CancelledThis trial explores whether cannabis use changes male reproductive health, including sperm quality, testosterone levels, and genetic markers in sperm. Men who use cannabis regularly and those who don't will be randomly assigned to vape cannabis with different THC doses, a placebo…
Phase 1 • Sponsor: Kanako Hayashi • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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One-Hour sperm wait could boost IVF success, new study suggests
Knowledge-focused OngoingThis study compares two sperm collection timings—1 hour versus the usual 2-5 days of abstinence—to see which leads to more embryos with normal chromosomes during IVF. Researchers will track embryo health and pregnancy rates in 187 women. The goal is to find a simple way to improv…
Sponsor: UConn Health • Aim: Knowledge-focused
Last updated Jul 11, 2026 00:00 UTC
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Which embryo is best? new study aims to boost IVF success
Knowledge-focused OngoingThis study looks at two methods for choosing which embryo to transfer during IVF: the standard way (looking at shape) and a newer way that also tracks how fast the embryo grows. The goal is to see which method leads to more live births. About 520 couples having their first or sec…
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Fertility study probes genetic test for men with no sperm in ejaculate
Knowledge-focused OngoingThis study reviews medical records from about 400 couples where the male partner has a condition called non-obstructive azoospermia (NOA), meaning no sperm is found in the semen. All couples used IVF with a special sperm injection technique. The goal is to see if testing embryos …
Sponsor: Inception Fertility Research Institute, LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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Watching embryos grow: a new way to pick the best for IVF?
Knowledge-focused By invitation onlyThis study watches embryos grow using time-lapse cameras and compares their development to genetic test results. Researchers hope to find visual clues that indicate a healthy embryo. 2000 IVF patients are taking part. If a link is found, it could lead to a less invasive way to ch…
Sponsor: Gattaca Genomics • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Could a second ejaculate boost IVF success? new trial investigates
Knowledge-focused OngoingThis study looks at whether using sperm from a second ejaculate (collected 1-2 hours after the first) can improve fertilization and embryo quality in ICSI, a type of IVF. Researchers will compare sperm quality and pregnancy outcomes between first and second ejaculates in 108 coup…
Sponsor: Ain Shams University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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New biobank aims to unlock secrets of infertility and pregnancy
Knowledge-focused By invitation onlyThis study is creating a biobank—a collection of blood samples and health data—to help researchers better understand gynecological disorders, infertility in men and women, and pregnancy-related conditions. Up to 3,000 participants will provide samples at San Raffaele Hospital in …
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC