Fertility drug trial for men with no sperm pulled before it began

NCT ID NCT03615547

Terminated Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aimed to see if the drug clomiphene citrate could help men with a condition called non-obstructive azoospermia, where the body produces little to no sperm. The plan was to give the drug or a placebo for nine months, then check if sperm could be found in the semen or through a second surgical extraction. However, the trial was withdrawn before enrolling any participants, so we don't know if the drug would have helped.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Clomiphene citrate
What this could lead to: If it had worked, this could have offered men with non-obstructive azoospermia a better chance of fathering their own biological children through a second sperm extraction procedure.
What could go wrong: The trial was withdrawn before any participants were enrolled, so no results are available. Previous studies on hormonal therapy for this condition have been small and inconsistent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for AZOOSPERMIA, NONOBSTRUCTIVE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

azoospermia spermatogenic failure 3 spermatogenic failure, Y-linked, 2

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AZOOSPERMIA, NONOBSTRUCTIVE

Contacts and locations

Locations

Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant

Bron, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.