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IVF scheduling showdown: natural cycle vs hormone cycle for embryo transfer

NCT ID NCT06053827

Knowledge-focused Sponsor: Clinique Ovo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at over 1,200 women under 40 who had a frozen embryo transfer. Some used a natural cycle with no hormones, while others took estrogen and progesterone to mimic a natural cycle. The goal was to see which method leads to more pregnancies. Results could help clinics decide the best way to schedule transfers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study shows one method works better, it could help doctors choose the best approach for frozen embryo transfers, potentially improving pregnancy success rates.
What could go wrong
This is a completed observational study, not a controlled trial, so results may not apply to all patients. Differences in pregnancy rates could be small or due to other factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,207 people

The number who actually took part.

Started

Sep 2023

Finished

Jul 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Data spreadsheet from Jan 2022 to March 2023 of patients undergoing natural or substituted frozen embryo transfer

Ages

Up to 40 years

Sex

Female participants only

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \< 40 years old * Women having undergone either a frozen embryo transfer in natural cycle or substituted cycle * IVF and FET cycles done at Clinique OVO Exclusion Criteria: * egg or embryo recipient * History of recurrent miscarriages, defined as ≥ 3 consecutive losses * Patients that needed Viagra, Plasma-Rich Platelet (PRP) or other modalities to improve their endometrial thickness * Uterine abnormalities * Abnormal hormonal profiles * FET Stimulated cycles * History of recurrent implantation failure defined as failed ≥ 2 euploid embryos transfer or ≥ 3 blastocysts

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Conditions

The condition(s) this trial relates to.

infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fertility disorders

Contacts and locations

Locations

  • Clinique Ovo

    Montreal, Quebec, H4P 2S4, Canada

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