New IVF medium may help those with low fertilization rates

NCT ID NCT05722067

Completed Disease control Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a ready-to-use calcium ionophore medium (GM508 CultActive) on eggs from 68 IVF patients who had low fertilization rates, poor embryo quality, or were over 40. The medium was applied shortly after sperm injection to try to improve fertilization and embryo development. The goal was to see if it could increase normal fertilization and high-quality blastocyst formation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: calcium ionophore (GM508 CultActive) medium
What this could lead to: If it works, this could help people with low fertilization rates or poor embryo quality have better success with IVF.
What could go wrong: This was a small, completed study with no phase designation, so results may not apply to all IVF patients. The treatment is a lab procedure, not a drug, and success depends on many factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

infertility disorder long QT syndrome 3 ventricular fibrillation, paroxysmal familial, type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTIFICIAL OOCYTE ACTIVATION INFERTILITY IVF

Contacts and locations

Locations

Chang Gung Memorial Hospital

Kaohsiung City, 123, Taiwan

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