INFERTILITY

This study tested a new ovarian stimulation method called NATOS for 129 women with good fertility outlooks undergoing IVF. The goal was to see if keeping estrogen levels closer to natural levels improves live birth rates compared to standard treatment. The approach aims to balanc…

This study tested a high dose of the fertility drug follitropin delta combined with hCG in 118 women undergoing IVF. The goal was to see if it could increase the number of good-quality embryos. Participants were women aged 18 to 42 with regular cycles. The study was completed and…

This study tested whether giving a small daily dose of a hormone called HMG after egg retrieval can improve the chance of a live birth in women undergoing IVF. 600 women aged 20-40 participated. The researchers measured live birth rates, pregnancy rates, and miscarriage rates to …

This study looked at whether a step-up dose of the drug letrozole helps women with PCOS ovulate better than the standard low dose. 70 infertile women with PCOS took either the step-up or standard dose for up to 3 menstrual cycles. Researchers tracked follicle growth, uterine lini…

This study looked at 87 IVF patients who had no eggs retrieved during their first egg collection attempt. Researchers tested whether giving a second ovulation trigger could successfully retrieve eggs. The goal was to find a way to salvage the cycle and avoid losing the eggs entir…

This study tested a nursing care program based on Levine's Conservation Model to help women with infertility feel less stressed and more supported. Eighty women in Egypt were split into two groups: one received the special nursing care, the other got standard care. The program ai…

This study tested whether giving an extra hormone (FSH) along with the standard hCG trigger before egg retrieval improves egg quality and pregnancy rates in IVF. 232 people undergoing IVF participated. The goal was to mimic the natural hormone surge to potentially increase fertil…

This study tested whether a medication reminder app on smartphones helps people undergoing IVF remember to take their fertility drugs. 387 patients were split into two groups: one used the app, the other did not. Researchers compared how often each group forgot medication, how sa…

This study looks at whether a new pain management protocol can reduce pain for people undergoing in vitro fertilization (IVF). Researchers compared pain scores from 206 patients who received the new protocol to data from an earlier study. The goal is to see if the new approach he…

This study tested a ready-to-use liquid called GM508 CultActive on 68 IVF patients who had low fertilization rates, poor embryo quality, or were over 40. The goal was to see if it could improve fertilization and embryo development. The treatment was applied to eggs during IVF to …

This study looked at whether Acceptance and Commitment Therapy (ACT) can help people struggling with the emotional pain of infertility. Nine adults with infertility took part in 12 therapy sessions. The goal was to see if they found the therapy helpful and if it reduced their str…

This study tested whether a microfluidic chip can select healthier sperm for IVF compared to the standard method. About 393 couples with unexplained infertility and a history of poor embryo quality took part. The goal was to see if the chip leads to more high-quality embryos on d…

This study looked at whether psychological support could help reduce anxiety in women about to undergo an egg retrieval procedure with general anesthesia. 180 women participated, and researchers compared those who received psychological interventions to those who did not. The mai…

This study tested a supportive care program based on Swanson's Caring Theory to help couples undergoing IVF or other assisted reproductive treatments. 50 couples were randomly assigned to receive either the supportive program (education and counseling) or routine care. The goal w…

This study looked at whether a short video explaining IVF medications could help women feel better emotionally and improve their quality of life during treatment. 62 women having IVF for the first time took part. The researchers measured anxiety, distress, and quality of life to …

This study looked at whether losing weight before in vitro fertilization (IVF) helps overweight and obese women have a live birth. Researchers followed 197 women aged 20-36 who were trying to get pregnant for the first time with IVF. Some women followed a diet and exercise progra…

This study tested whether taking melatonin supplements could improve fertility treatment outcomes for women undergoing IVF. Researchers gave 80 women either melatonin or a placebo during their ovarian stimulation cycle. They measured hormone levels, egg quality, embryo developmen…

This study compared two advanced embryo culture systems used in IVF to see which one helps embryos grow better. Researchers looked at how many embryos successfully implanted in the womb. The goal is to improve success rates for people struggling with infertility.

This study looked at how a single shot of Gonadotropins-IBSA, a fertility drug, is processed by the body. It involved 29 healthy women of childbearing age. The goal was to understand the drug's levels over time and check for side effects, not to treat infertility directly.

This study looked at whether using a milder or more intense hormone stimulation during IVF leads to better-quality embryos. It involved 110 women aged 35–40 with low ovarian reserve. Researchers compared the number of good-quality blastocysts from each approach to help guide futu…

This study examined genes in the cells that surround a woman's eggs to see if they can predict which embryos will lead to a pregnancy. Researchers looked at 137 women undergoing IVF to find patterns in these genes. The goal is to improve embryo selection and increase the chance o…

This study looked at whether less invasive methods, like a vaginal swab or collecting fluid from the womb, can give the same information as a standard biopsy when analyzing the microbiome (the community of bacteria) in the reproductive tract. Fifty-seven women aged 18-50 provided…

This study followed 214 children born from two different fertility treatments—CAPA-IVM and conventional IVF—to see if their development and behavior differed at age 5. Researchers used parent questionnaires to check communication, motor skills, problem-solving, emotions, and grow…

This study tested a new way to choose sperm for in vitro fertilization (IVF). Instead of an embryologist picking sperm by hand, they used sperm that naturally attached to the egg's outer layer (zona pellucida). The goal was to see if this method leads to better embryo development…

This study looked at 400 couples (both fertile and infertile) to see how diet, lifestyle, and genetics affect the chance of getting pregnant. Researchers checked eating habits, body measurements, and blood tests. The goal was to find out if certain foods or habits are linked to f…

This study looked at whether the type of freezing solution used for donated eggs affects pregnancy rates. Researchers compared a solution made just for eggs to a universal one that works for all stages. They studied 111 couples receiving donated eggs and found no major difference…

This study looked at people with a rare condition that causes low or no gonadotropin hormones, which can delay puberty and cause infertility. Researchers measured hormone levels, did imaging scans, and tested senses like smell and hearing to better understand how the body control…

This completed Phase 1 study looked at how fertility hormones (FSH and hCG) are absorbed and processed by the body after daily injections in 28 healthy women. The goal was to understand the drug's pharmacokinetics, not to treat infertility directly. Participants had their pituita…

This study tested whether analyzing the fluid around embryos with a special scanner (NMR) can quickly and cheaply tell if an embryo has the right number of chromosomes. 30 people undergoing IVF and genetic testing took part. The goal was to see if this method could replace the cu…

This study looked at how in vitro fertilization (IVF) affects the quality of life of working women. Researchers followed 200 women starting their first IVF treatment, using surveys to measure their emotional, physical, and social well-being over 18 months. The goal was to underst…

This study tested whether a simple mindfulness technique—paying close attention to changes in body sensations—could improve well-being for couples struggling with infertility. Researchers enrolled 70 people (infertile patients and their partners) who were about to start their fir…

This study looked at 158 women undergoing intrauterine insemination (IUI) to see if progesterone levels on the day of the procedure are linked to pregnancy rates. IUI is a simpler, cheaper fertility treatment than IVF, but success rates are modest. The goal was to find a way to b…

This study looked at 148 infertile women with an overactive immune system in the uterus who were treated with glucocorticoids (a type of anti-inflammatory drug) before embryo transfer. Some women had a sensitivity test to see if the drug would work for them, while others did not.…

This study tested a new method for preparing sperm samples used in IVF or ICSI to see if it helps embryos develop better. It involved 41 couples with infertility, comparing the new method to the standard one using eggs from the same woman. The main goal was to see if more embryos…

This study tested whether robots and artificial intelligence could automate key steps in the IVF process, such as preparing sperm and eggs, injecting sperm into eggs, and growing embryos. Researchers compared the automated workflow to the standard manual approach using 42 patient…

This study looked at whether transferring embryos in two separate steps (sequential double embryo transfer) leads to more live births than transferring them all at once. Researchers compared 778 couples undergoing IVF, matching similar patients in each group. The goal was to see …

This study looked at whether testing the fluid around an embryo for genetic health can help doctors choose the best embryo to transfer during IVF. Over 1,100 couples took part, and the test was compared to the usual method of just looking at the embryo's shape. The goal was to se…