Could a pill before IVF boost baby chances for endometriosis patients?

NCT ID NCT04173169

Completed Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tested whether taking Elagolix (a hormone-blocking pill) for two months before IVF could improve live birth rates in women with endometriosis. 103 women participated, and the main goal was to see if more babies were born after this pre-treatment. The study compared Elagolix to a placebo to find out if it helps overcome infertility linked to endometriosis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Elagolix (Orlissa)
What this could lead to: If successful, this could offer a new pre-treatment option to improve IVF success rates for women with endometriosis-related infertility.
What could go wrong: This is a single completed trial with 103 participants, so results may not apply to all. Elagolix can cause side effects like hot flashes and bone density loss.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometriosis infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOSIS INFERTILITY

Contacts and locations

Locations

Duke Fertility

Morrisville, North Carolina, 27560, United States
Johns Hopkins, Division of Reproductive Science and Women's Health Research

Baltimore, Maryland, 21205, United States
Northwestern University Department of Obstetrics and Gynecology

Chicago, Illinois, 60611, United States
University of Colorado Department of Obstetrics & Gynecology

Aurora, Colorado, 80045, United States
Yale School of Medicine Dept.of Ob/Gyn & Reproductive Sciences

New Haven, Connecticut, 06520, United States

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