New hope for women with low ovarian response: cheaper drug may work just as well
NCT ID NCT06212102
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a cheaper hormone (dydrogesterone) works as well as a standard drug (GnRH antagonist) to prevent early ovulation in women with low ovarian response undergoing double ovarian stimulation. About 120 women will be randomly assigned to one of the two treatments. The main goal is to see which approach lowers medication costs per egg retrieved and improves pregnancy rates.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2024
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 to 44 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patients belonging to Poseidon group 4 Exclusion Criteria: * PCOS * Endometriosis * History of recurrent abortion
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Bedaya Hospital
NOT_YET_RECRUITINGGiza, Egypt
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Cairo University
RECRUITINGCairo, Cairo Governorate, Egypt
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Other studies related to the condition(s) this trial covers.
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- A Hormone-Free IVF path? Lab-Matured eggs put to the test
- Can a fertility drug's safety be tracked in real-world use?
- Can a suppository or a local block take the pain out of fertility testing?
- Can a lab technique mature eggs more gently for IVF?