One extra shot around embryo transfer may lift IVF live birth rates
NCT ID NCT02357654
First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time
Summary
This trial tests whether a single injection of a GnRH agonist given around the time of embryo transfer can improve the chance of a live birth in women under 40 undergoing IVF, ICSI, or frozen embryo transfer. Participants receive either the GnRH shot or a placebo, and researchers track live birth rates, implantation, clinical pregnancy, and risk of ovarian hyperstimulation syndrome. The goal is to see if this simple hormonal boost helps the uterus support a pregnancy after embryo transfer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- GnRH agonist (single injection)
- What this could lead to
- If it works, this simple additional shot could increase the chance of a live birth after IVF or frozen embryo transfer.
- What could go wrong
- This is a single-center Phase 4 trial; results may not apply to all IVF patients. The GnRH agonist carries a small risk of ovarian hyperstimulation syndrome (OHSS).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University Reproductive Associates
RECRUITINGHasbrouck Heights, New Jersey, 07604, United States
Contact
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