Could a simpler hormone regimen boost IVF success? new trial investigates
NCT ID NCT06644794
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial compares two ways to prepare the womb lining for a frozen embryo transfer: a modified natural cycle using progesterone only, versus standard hormone replacement therapy. The study will enroll 336 women aged 21-44 with regular cycles to see which method leads to more live births. The modified natural cycle aims to be more convenient and potentially safer by reducing the need for monitoring and lowering pregnancy complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Progesterone and estradiol (hormone therapies)
- What this could lead to
- If this trial succeeds, it could show that a simpler, more natural hormone preparation method leads to more live births and fewer pregnancy complications for women undergoing frozen embryo transfer.
- What could go wrong
- This is a phase 3 trial, but it is still relatively small (336 participants) and focuses on a specific group of women with regular cycles. Results may not apply to all infertility patients, and the new method may not prove superior.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for INFERTILITY are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
RECRUITINGJinan, Shandong, 250014, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A questionnaire to empower fertility patients — a pilot study puts it to the test
- Obesity may blunt the Brain's ovulation signal, study hints
- Could a simple ultrasound replace an invasive scope for Post-Surgery uterine checks?
- Could a fibroid drug help women with adenomyosis finally achieve a live birth?
- Hormone shot before embryo transfer may boost pregnancy chances in severe endometriosis
- One extra shot around embryo transfer may lift IVF live birth rates