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Sperm sorting showdown: can a microchip pick the best sperm for pregnancy?

NCT ID NCT05693220

Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Researchers at the University of California, San Francisco, are comparing two ways to prepare sperm before intrauterine insemination (IUI). One method uses a microfluidic device called Zymot Multi to sort sperm, while the other uses density gradient centrifugation, a standard lab technique. The trial will enroll 270 women under 41 who are having IUI for the first time with partner sperm. The goal is to see which method leads to more clinical pregnancies over multiple IUI cycles.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Microfluidic sperm sorting using the Zymot Multi device
What this could lead to
If microfluidic sorting works better, it could become a preferred method for preparing sperm before IUI, potentially improving pregnancy rates for couples with infertility.
What could go wrong
This is a single-center study with 270 participants, so results may not apply to everyone. The method might not improve pregnancy rates, and it could be more expensive or technically difficult to implement widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 270 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2023

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing intrauterine insemination * Patient assigned female at birth with age \<41 Exclusion Criteria: * Any significant disease or psychiatric disorder that would interfere with the consenting process * Prior intrauterine insemination * Use of frozen donor sperm * Non-English speaker

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Conditions

The condition(s) this trial relates to.

anovulation infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anovulation Fertility disorders Infertility Infertility secondary Infertility unexplained Reproductive issues

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UCSF Center for Reproductive Health

    RECRUITING

    San Francisco, California, 94158, United States

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