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Could freezing sperm outsmart father time?

NCT ID NCT07814235

Knowledge-focused Sponsor: IVI Murcia Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers at IVI Murcia are studying whether freezing sperm can preserve its quality and molecular features that may decline with age. Men aged 18 to 65 provide a semen sample and a blood sample. Each semen sample is split into fresh, slow-frozen, and vitrified portions. The team compares sperm count, motility, DNA fragmentation, DNA methylation, and telomere length across these groups to see how age and freezing affect sperm characteristics.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sperm cryopreservation (slow freezing and vitrification)
What this could lead to
If freezing preserves sperm quality and DNA markers, men could store younger sperm for later use, potentially reducing age-related fertility risks.
What could go wrong
This is a small laboratory study of 45 men, so it cannot prove that frozen sperm leads to better pregnancy outcomes. Freezing itself can damage sperm, and the long-term effects of using aged, frozen samples remain unknown.

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Study facts

What this study's own registry entry says, in plain language.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult men aged 18-65 years attending IVI Murcia for semen analysis, fertility assessment, semen donation, or assisted reproduction treatment who meet the study eligibility criteria and provide informed consent. Participants will provide semen and blood samples for laboratory assessment of sperm quality and molecular characteristics before and after cryopreservation.

Ages

18 to 65 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male participants aged 18 to 65 years * Attending IVI Murcia for semen analysis and/or assisted reproduction treatment * Able and willing to provide written informed consent * Willing to provide a semen sample and a blood sample for research purposes Exclusion Criteria: * Previous diagnosis of azoospermia or severe oligozoospermia (sperm concentration \<1 million sperm/mL) * Known chromosomal abnormality (abnormal karyotype) * Known Y chromosome microdeletion * Febrile illness within the previous 3 months * Presence of varicocele * Current use of vitamin or antioxidant supplements intended to improve semen quality

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Conditions

The condition(s) this trial relates to.

infertility disorder male infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Assisted reproduction technologies Epigenetic aging Infertility Male fertility

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • IVI Murcia

    RECRUITING

    Murcia, Murcia, 30007, Spain

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