Fertility drug showdown: which works better for IVF in china?

NCT ID NCT06173869

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed Phase 3 trial compared two fertility drugs—follitropin delta (Rekovelle) and follitropin alfa (Gonal-F)—in 301 Chinese women undergoing IVF. The goal was to see which starting dose leads to the best number of eggs retrieved. Participants received daily injections for up to 20 days, with doses adjusted based on response. Results may help personalize treatment for better IVF outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Follitropin delta (Rekovelle) and follitropin alfa (Gonal-F)
What this could lead to
If successful, this could help doctors choose the best starting dose of follitropin delta for Chinese women undergoing IVF, potentially improving egg retrieval outcomes.
What could go wrong
This is a completed Phase 3 trial, but results are not yet published. The study only included Chinese women aged 20-40, so findings may not apply to other populations or ages.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

301 people

The number who actually took part.

Started

Mar 2024

Finished

May 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Signed and dated Informed Consent Form for participation in the trial, obtained before any trial-related procedures. * In good physical and mental health in the judgement of the investigator. * Chinese pre-menopausal female between the ages of 20 and 40 years; at least 20 years (including the 20th birthday) when signing the informed consent and no more than 40 years (up to the day before the 41st birthday) at the time of randomisation. * Eligible for ovarian stimulation with a dose equivalent to 150 IU GONAL-F or 225 IU GONAL-F, as judged by the investigator. * Body mass index (BMI) between 17.5 and 32.0 kg/m2 (both inclusive) at screening. * Infertile women diagnosed with tubal infertility, unexplained infertility, endometriosis stage I/II or with partners diagnosed with male factor infertility, eligible for in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) using fresh or frozen ejaculated sperm from male partner or sperm donor * Infertility for at least one year before randomisation for subjects \<35 years or for at least 6 months for subjects ≥35 years (criteria not applicable in case of tubal or severe male factor infertility). * Regular menstrual cycles of 24-35 days (both inclusive), presumed to be ovulatory. * Transvaginal ultrasound documenting presence and adequate visualisation of both ovaries, without evidence of significant abnormality. Both ovaries must be accessible for oocyte retrieval. * Early follicular phase (cycle day 2-4) serum levels of follicle-stimulating hormone (FSH) between 1 and 15 IU/L (results obtained within 3 months prior to randomisation). * Serum anti-Müllerian hormone (AMH) concentration of ≤35 pmol/L at screening. Exclusion Criteria: * Primary ovarian failure. * More than three previous controlled ovarian stimulation cycles initiated, regardless of outcome. * History of previous episode of OHSS, exuberant ovarian response to gonadotropins, or polycystic ovarian syndrome. * Known endocrine or metabolic abnormalities (pituitary, adrenal, pancreas, liver or kidney) which can compromise participation in the trial with the exception of controlled thyroid function disease. * Known tumours of the ovary, breast, uterus, adrenal gland, pituitary or hypothalamus which would contraindicate the use of gonadotropins. * Fibroid tumours of the uterus incompatible with pregnancy. * Currently breast-feeding. * Known inherited or acquired thrombophilia disease. * Active arterial or venous thromboembolism or severe thrombophlebitis, or a history of these events. * Known porphyria.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Ferring Investigational Site

    Shushan, Anhui, 230032, China

  • Ferring Investigational Site

    Yuzhong, Chongqing Municipality, 401147, China

  • Ferring Investigational Site

    Guangzhou, Guandong, 510120, China

  • Ferring Investigational Site

    Guangzhou, Guangdong, 510000, China

  • Ferring Investigational Site

    Zhengzhou, Henan, China

  • Ferring Investigational Site

    Nanchang, Jiangxi, 330038, China

  • Ferring Investigational Site

    Shengyang, Liaoling, 110004, China

  • Ferring Investigational Site

    Shanghai, Shanghai Municipality, 201204, China

  • Ferring Investigational Site

    Chengdu, Sichuang, 610041, China

  • Ferring Investigational Site

    Tianjin, Tianjin Municipality, 300052, China

  • Ferring Investigational Site

    Xiaobailou, Tianjin Municipality, 300052, China

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