Fertility drug showdown: which works better for IVF in china?
NCT ID NCT06173869
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 3 trial compared two fertility drugs—follitropin delta (Rekovelle) and follitropin alfa (Gonal-F)—in 301 Chinese women undergoing IVF. The goal was to see which starting dose leads to the best number of eggs retrieved. Participants received daily injections for up to 20 days, with doses adjusted based on response. Results may help personalize treatment for better IVF outcomes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Follitropin delta (Rekovelle) and follitropin alfa (Gonal-F)
- What this could lead to
- If successful, this could help doctors choose the best starting dose of follitropin delta for Chinese women undergoing IVF, potentially improving egg retrieval outcomes.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet published. The study only included Chinese women aged 20-40, so findings may not apply to other populations or ages.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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301 people
The number who actually took part.
- Started
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Mar 2024
- Finished
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May 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Signed and dated Informed Consent Form for participation in the trial, obtained before any trial-related procedures. * In good physical and mental health in the judgement of the investigator. * Chinese pre-menopausal female between the ages of 20 and 40 years; at least 20 years (including the 20th birthday) when signing the informed consent and no more than 40 years (up to the day before the 41st birthday) at the time of randomisation. * Eligible for ovarian stimulation with a dose equivalent to 150 IU GONAL-F or 225 IU GONAL-F, as judged by the investigator. * Body mass index (BMI) between 17.5 and 32.0 kg/m2 (both inclusive) at screening. * Infertile women diagnosed with tubal infertility, unexplained infertility, endometriosis stage I/II or with partners diagnosed with male factor infertility, eligible for in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) using fresh or frozen ejaculated sperm from male partner or sperm donor * Infertility for at least one year before randomisation for subjects \<35 years or for at least 6 months for subjects ≥35 years (criteria not applicable in case of tubal or severe male factor infertility). * Regular menstrual cycles of 24-35 days (both inclusive), presumed to be ovulatory. * Transvaginal ultrasound documenting presence and adequate visualisation of both ovaries, without evidence of significant abnormality. Both ovaries must be accessible for oocyte retrieval. * Early follicular phase (cycle day 2-4) serum levels of follicle-stimulating hormone (FSH) between 1 and 15 IU/L (results obtained within 3 months prior to randomisation). * Serum anti-Müllerian hormone (AMH) concentration of ≤35 pmol/L at screening. Exclusion Criteria: * Primary ovarian failure. * More than three previous controlled ovarian stimulation cycles initiated, regardless of outcome. * History of previous episode of OHSS, exuberant ovarian response to gonadotropins, or polycystic ovarian syndrome. * Known endocrine or metabolic abnormalities (pituitary, adrenal, pancreas, liver or kidney) which can compromise participation in the trial with the exception of controlled thyroid function disease. * Known tumours of the ovary, breast, uterus, adrenal gland, pituitary or hypothalamus which would contraindicate the use of gonadotropins. * Fibroid tumours of the uterus incompatible with pregnancy. * Currently breast-feeding. * Known inherited or acquired thrombophilia disease. * Active arterial or venous thromboembolism or severe thrombophlebitis, or a history of these events. * Known porphyria.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ferring Investigational Site
Shushan, Anhui, 230032, China
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Ferring Investigational Site
Yuzhong, Chongqing Municipality, 401147, China
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Ferring Investigational Site
Guangzhou, Guandong, 510120, China
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Ferring Investigational Site
Guangzhou, Guangdong, 510000, China
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Ferring Investigational Site
Zhengzhou, Henan, China
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Ferring Investigational Site
Nanchang, Jiangxi, 330038, China
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Ferring Investigational Site
Shengyang, Liaoling, 110004, China
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Ferring Investigational Site
Shanghai, Shanghai Municipality, 201204, China
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Ferring Investigational Site
Chengdu, Sichuang, 610041, China
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Ferring Investigational Site
Tianjin, Tianjin Municipality, 300052, China
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Ferring Investigational Site
Xiaobailou, Tianjin Municipality, 300052, China
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Other studies related to the condition(s) this trial covers.
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