Womb transplant: a temporary fix for a permanent infertility?
NCT ID NCT05646992
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This study tests whether a temporary uterus transplant from a living donor can allow women with uterine factor infertility—who lack a functioning uterus—to become pregnant and deliver a healthy baby. Recipients receive immunosuppressive drugs to prevent rejection, and the uterus is removed after childbirth. The trial involves about 40 participants and follows recipients for up to five years, with children followed into adulthood.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Uterus transplantation from a living donor, with immunosuppressive drugs (tacrolimus and azathioprine) to prevent rejection.
- What this could lead to
- If successful, this could offer a path to pregnancy and childbirth for women born without a functioning uterus, using a temporary transplant.
- What could go wrong
- This is an early-stage surgical procedure with risks from major surgery and immunosuppression; success is not guaranteed and the uterus is removed after childbirth.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Johns Hopkins University School of Medicine
RECRUITINGBaltimore, Maryland, 21287, United States