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Antioxidant supplement may boost IVF outcomes for older women

NCT ID NCT07685431

Disease control Sponsor: Kaohsiung Veterans General Hospital. Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 06, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study tests whether taking alpha-lipoic acid (ALA), a powerful antioxidant, for two months before IVF can improve egg quality and pregnancy rates in women aged 35-45 with infertility. Researchers will compare 30 women who take ALA with 30 who do not, measuring embryo quality, mitochondrial function in egg-supporting cells, and clinical pregnancy and live birth rates. The goal is to see if this simple supplement can counteract age-related fertility decline.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Alpha-lipoic acid (ALA), an antioxidant supplement
What this could lead to
If it works, this could point toward a simple supplement to improve egg quality and IVF success in older women.
What could go wrong
This is a small, early study with only 60 participants. The supplement may not improve pregnancy or live birth rates, and results may not apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 35-45 years * BMI 18-35 kg/m² * Planning to undergo IVF treatment using own oocytes Exclusion Criteria: * Primary ovarian insufficiency * Azoospermia or severe male-factor infertility in the partner * Congenital uterine anomaly * Severe intrauterine adhesion * Known chromosomal anomaly in either partner * Malignancy * Recipient of donor oocytes * Known hypersensitivity/allergy to alpha-lipoic acid

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Conditions

The condition(s) this trial relates to.

female infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Female infertility due to diminished ovarian reserve

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kaohsiung Veterans General Hospital

    RECRUITING

    Kaohsiung City, 813, Taiwan

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