PRP treatment may boost IVF success by reshaping uterine immune cells

NCT ID NCT07535190

Recruiting now Disease control Sponsor: Nadezhda Women's Health Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving platelet-rich plasma (PRP) inside the uterus can improve the immune environment and thickness of the lining in women undergoing IVF. Researchers will take biopsies before and after PRP to measure changes in immune cells. The goal is to see if PRP can make the uterus more receptive to embryo transfer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: platelet-rich plasma (PRP)
What this could lead to: If it works, this could point toward a simple way to improve IVF success by making the uterine lining more receptive to embryo implantation.
What could go wrong: This is a small, early-phase study with only 50 participants. It focuses on immune cell changes and lining thickness, not directly on pregnancy rates, so benefits remain uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

female infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FEMALE INFERTILITY IVF PATIENTS

Contacts and locations

Locations

Nadezhda Women's Health Hospital
RECRUITING

Sofia, Sofia, 1330, Bulgaria

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