Could a longer clomid regimen boost IVF success for women with low egg supply?

NCT ID NCT06701071

Recruiting now Disease control Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

This study compares a longer course of the fertility drug Clomid against the standard short course for women with diminished ovarian reserve undergoing IVF. The goal is to see if the extended protocol leads to more mature eggs retrieved while reducing the number of injections and overall cost. 120 participants will be randomly assigned to one of the two protocols.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Clomiphene citrate (Clomid)
What this could lead to: If successful, this could offer a more effective and less burdensome stimulation protocol for women with diminished ovarian reserve, potentially increasing the number of mature eggs retrieved during IVF.
What could go wrong: This is a Phase 4 trial with only 120 participants, so results may not apply to all patients. The longer protocol may not improve outcomes and could increase side effects like premature ovulation.

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Conditions

The condition(s) this trial relates to.

female infertility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFERTILITY, FEMALE

Contacts and locations

Locations

HRC Fertility
RECRUITING

Pasadena, California, 91101, United States

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