Could a thyroid hormone boost fertility in PCOS? new trial tests combination therapy
NCT ID NCT06041204
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether adding levothyroxine (a thyroid hormone) to the standard fertility drug letrozole helps women with PCOS and mild underactive thyroid ovulate and get pregnant. Two hundred women will be randomly assigned to receive either letrozole alone or letrozole plus levothyroxine for up to six months. The goal is to see if the combination leads to higher pregnancy and live birth rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- letrozole and levothyroxine
- What this could lead to
- If successful, this could show that adding levothyroxine to letrozole improves ovulation and pregnancy rates in women with both PCOS and subclinical hypothyroidism.
- What could go wrong
- This is a relatively small, early-stage trial with 200 participants. The results may not apply to all women, and the benefit of adding levothyroxine might be small or absent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Al-Hussein University Hospital
RECRUITINGCairo, 11633, Egypt
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