Primary dysmenorrhea
MONDO:1060206A form of dysmenorrhea characterized by recurrent menstrual pain without any identifiable underlying pelvic pathology, representing a diagnosis of exclusion. Symptoms typically emerge within two years of menarche.
64 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Pilates or gym: which eases period pain best?
Symptom relief Not yet recruitingThis study tests whether Pilates or gym exercises better relieve pain from primary dysmenorrhea (period pain) in young women aged 17-25. Fifty-two participants will do either Pilates or gym workouts three times a week for three months. Researchers will measure pain intensity, sym…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 14:03 UTC
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Tapping away period pain: emotional freedom techniques put to the test
Symptom relief Not yet recruitingThis study tests whether Emotional Freedom Techniques (EFT), a therapy that combines tapping on acupressure points with focused thoughts, can reduce pain intensity, pain-related worrying, and emotional distress in nursing students who suffer from painful periods. Participants are…
Phase: NA • Sponsor: Ataturk University • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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New wearable sleeve aims to zap period pain without pills
Symptom relief Not yet recruitingThis study tests a wearable sleeve with semiconductors that claim to boost blood flow and reduce pain. One hundred women with painful periods will wear either the active sleeve or a placebo version. The goal is to see if the sleeve can ease cramping and improve quality of life wi…
Phase: NA • Sponsor: University of California, Davis • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Talking therapy may ease period pain in teens
Symptom relief Not yet recruitingThis study tests a psychological program for teens aged 15-19 with painful periods. The program uses cognitive restructuring and psychoeducation to help them change negative thoughts and improve emotional control. Researchers will measure pain and coping skills before and after t…
Phase: NA • Sponsor: Universidad Autonoma de Baja California • Aim: Symptom relief
Last updated Jun 27, 2026 12:34 UTC
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Exercise at home may be the new painkiller for period cramps
Symptom relief Not yet recruitingThis study tests whether an 8-week home exercise program can reduce pain and improve walking and brain function in young women with painful periods. Eighty-six single women aged 18-25 with moderate to severe period pain will do 30-minute sessions three times a week, including rel…
Phase: NA • Sponsor: University of Sharjah • Aim: Symptom relief
Last updated Jun 27, 2026 12:33 UTC
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New supplement aims to soothe menstrual cramps without drugs
Symptom relief Not yet recruitingThis study tests whether a dietary supplement called CL25216 can help women with painful periods (primary dysmenorrhea). Eighty healthy women aged 25-40 will take either CL25216 or a placebo daily for 84 days. Researchers will measure changes in menstrual pain, pain duration, and…
Phase: NA • Sponsor: ApexCPG LLC • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Yoga may be the key to banishing period pain
Symptom relief Not yet recruitingThis study will test whether a structured yoga program can reduce pain and improve quality of life in 30 young women aged 18-25 with primary dysmenorrhea (painful periods). Participants will do breathing exercises, relaxation, and pelvic-focused yoga poses. Researchers will measu…
Phase: NA • Sponsor: Ankara University • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Could a vaginal pill ease severe period cramps?
Symptom relief Not yet recruitingThis early-stage trial tests whether a single vaginal dose of sildenafil (100 mg) can reduce painful uterine contractions during menstruation. About 50 adults with moderate-to-severe period pain will receive the drug or a placebo in two separate cycles. The study uses MRI to meas…
Phase: PHASE1 • Sponsor: Kevin Hellman • Aim: Symptom relief
Last updated Jun 27, 2026 12:03 UTC
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Massage therapy shows promise for menstrual cramps
Symptom relief Not yet recruitingThis pilot study tests if a gentle massage technique called manual lymphatic drainage (MLD) can reduce period pain in young women aged 18-25 with primary dysmenorrhea. Twenty participants will receive three monthly MLD sessions before their period. Researchers will measure pain, …
Phase: NA • Sponsor: Camilo Jose Cela University • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Mindfulness may soothe period pain without pills
Symptom relief Not yet recruitingThis study tests whether an 8-session mindfulness-based compassionate living program can help university students with painful periods feel less stress, less pain, and more in control. About 68 students will either take the training or receive no intervention. Researchers will me…
Phase: NA • Sponsor: Ataturk University • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Can learning about comfort reduce period cramps? new study investigates
Symptom relief Not yet recruitingThis study tests whether a comfort theory-based education program can help university students with primary dysmenorrhea (painful periods) feel better. The program involves three face-to-face sessions over three months, each lasting 40 minutes. Researchers will compare pain level…
Phase: NA • Sponsor: Ordu University • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Shocking period pain away? new trial tests nerve zap for cramps
Symptom relief Not yet recruitingThis study tests whether a device that sends mild electrical pulses to a nerve in the ankle (TTNS) can reduce pain and distress from period cramps. Thirty-six women with primary dysmenorrhea will receive either standard care (heat packs and stretches) or standard care plus TTNS f…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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No pills, just pressure: self-massage study targets menstrual cramps
Symptom relief Not yet recruitingThis study tests whether a daily 5-20 minute abdominal self-massage can reduce menstrual pain. 46 female students in Germany will track their pain and medication use via a smartphone app over up to 60 days. Each person acts as their own control, comparing massage days to no-massa…
Phase: NA • Sponsor: University of Potsdam • Aim: Symptom relief
Last updated Jun 26, 2026 13:47 UTC
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Period pain plagues med students: new study to measure toll on grades and life
Knowledge-focused Not yet recruitingThis study will survey 402 female medical students at Sohag University to understand how period pain (primary dysmenorrhea) impacts their academic performance and quality of life. Participants will fill out two questionnaires about their pain and its effects. The goal is to gathe…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Period pain study aims to uncover hidden health impacts
Knowledge-focused Not yet recruitingThis study will compare 70 women with and without primary dysmenorrhea (painful periods) to see how the condition affects pain sensitivity, joint flexibility, physical activity, breathing strength, attitudes about menstruation, and mood. Researchers hope to identify key areas aff…
Phase: NA • Sponsor: Izmir Democracy University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC