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Single injection could replace opioids after bunion surgery

NCT ID NCT02471898

Completed Symptom relief Sponsor: Heron Therapeutics Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This phase 2 trial tests whether a single local dose of HTX-011, a long-acting anesthetic, can reduce pain after bunionectomy better than a placebo. About 70 adults undergoing foot surgery receive either the drug or a saline injection, and their pain is tracked over 24 hours. The goal is to see if this approach can provide effective pain relief without the need for opioid pills.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
an experimental long-acting local anesthetic called HTX-011 (also known as ZYNRELEF)
What this could lead to
If it works, this could offer a new way to manage post-surgical pain without opioids.
What could go wrong
This is an early phase 2 trial with only 71 participants, so results may not apply to all surgeries or patients. Pain relief may not be significantly better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA

Contacts and locations

Locations

  • Study site

    Pasadena, California, 91105, United States

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