Could talk therapy boost brain function in schizophrenia?
NCT ID NCT07671040
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This pilot study tested whether adding structured supportive psychotherapy to the antipsychotic risperidone could improve cognitive function and reduce inflammation in 44 hospitalized adults with schizophrenia. Participants received either risperidone plus 12 weekly talk therapy sessions or risperidone plus unstructured conversation. The study measured changes in thinking skills and a blood marker of inflammation after 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- structured supportive psychotherapy
- What this could lead to
- If this approach works, it could point toward a way to improve thinking skills and reduce inflammation in people with schizophrenia, alongside standard medication.
- What could go wrong
- This is a small pilot study with only 44 participants, so results may not apply to everyone. The trial was registered after completion, which can introduce bias.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Psychiatry, Faculty of Medicine, Hasanuddin University
Makassar, South Sulawesi, 90245, Indonesia
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