Brain zaps and mindfulness: a new hope for veterans in pain?
NCT ID NCT05427201
First seen Jul 17, 2026 · Last updated Jul 17, 2026
Summary
This study tests whether combining a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) with a type of talk therapy called acceptance and commitment therapy (ACT) can help veterans who have both chronic pain and depression. The goal is to see if this integrated approach is feasible and can improve how well participants function in daily life. The trial enrolls veterans with long-term pain and major depression, and also uses brain-wave monitoring to look for signs of treatment response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- repetitive transcranial magnetic stimulation (rTMS) combined with acceptance and commitment therapy (ACT)
- What this could lead to
- If successful, this approach could offer a new, non-drug way to improve daily functioning for veterans suffering from both chronic pain and depression.
- What could go wrong
- This is a small, early feasibility study with only 31 participants, so results may not apply widely. The combination therapy may prove no better than existing treatments.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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VA San Diego Healthcare System, San Diego, CA
San Diego, California, 92161-0002, United States
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