Could a common ADHD drug boost brain power in schizophrenia?
NCT ID NCT05414058
First seen Jun 25, 2026 · Last updated Aug 13, 2026 · Updated 4 times
Summary
This study tested whether adding a long-acting stimulant (methylphenidate) to regular antipsychotic medication can improve thinking and daily function in people with schizophrenia or schizoaffective disorder. Thirty-five adults who were stable on their current treatment took the drug for a period, and researchers measured changes using a virtual reality test of daily living skills and a cognitive assessment. The goal was to see if this approach is safe and effective for treating negative and cognitive symptoms that often persist despite standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- methylphenidate extended-release (a stimulant medication)
- What this could lead to
- If it works, this could point toward a way to improve thinking and daily living skills in people with schizophrenia.
- What could go wrong
- This is a small, early-phase trial with only 35 people. Stimulants may worsen psychosis, so results may not be safe or effective for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Royal Ottawa Mental Health Centre
Ottawa, Ontario, K1Z 7K4, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a tailored self-management program improve health outcomes for those with serious mental illness?