Could a common ADHD drug boost brain power in schizophrenia?

NCT ID NCT05414058

First seen Jun 25, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This study tested whether adding a long-acting stimulant (methylphenidate) to regular antipsychotic medication can improve thinking and daily function in people with schizophrenia or schizoaffective disorder. Thirty-five adults who were stable on their current treatment took the drug for a period, and researchers measured changes using a virtual reality test of daily living skills and a cognitive assessment. The goal was to see if this approach is safe and effective for treating negative and cognitive symptoms that often persist despite standard care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
methylphenidate extended-release (a stimulant medication)
What this could lead to
If it works, this could point toward a way to improve thinking and daily living skills in people with schizophrenia.
What could go wrong
This is a small, early-phase trial with only 35 people. Stimulants may worsen psychosis, so results may not be safe or effective for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Royal Ottawa Mental Health Centre

    Ottawa, Ontario, K1Z 7K4, Canada

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